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Completed

NCT Number: NCT00633581

Efficacy of Vitamin C Injection on Fatigue in Workers After Work

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

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Key information

Conditions

Fatigue Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–49 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

DongGuk University International Hospital

Goyang-si, Gyeonggi-do, 410-773, South Korea

About this study

Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Company workers working at least 5 days a week from morning to evening
  • Volunteers who provided written informed consent

Exclusion criteria

  • Acute illness
  • Chronic disease such as diabetes, hypertension, liver disease, or renal disease
  • Previous history of renal stone or gout
  • Pregnant or lactating women
  • Hypersensitivity to vitamins or intravenous injections
  • History of vitamin supplements orally or parenterally within 2 days

Treatment and study plan

Ascorbic acid (Vitamin C)

Dietary Supplement

Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes

Other names: Ascorbic acid, Merit C

Normal saline

Dietary Supplement

Single intravenous injection of 120ml of normal saline over 30 minutes

Primary outcomes

  1. Degree of fatigue at the point of time with visual analogue scale from 0 to 10

    Time frame: Before intravenous vitamin C injection and right after completing injections, and one day later

Secondary outcomes

  1. Reactive oxygen species

    Time frame: Before intravenous vitamin C injections, right after completing injections, and one day later

  2. Plasma vitamin C level

    Time frame: Before intravenous vitamin C injections and right after completing injections

Sponsors and collaborators

Lead sponsor

DongGuk University

Other

Collaborators

  • Korean Association For Vitamin Research

Registry information

Official study title

Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Mar 12, 2008
Registry last updated
Apr 10, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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