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NCT Number: NCT05361837

Efficacy of Serratus Anterior Plane Block With Dexmedetomidine During Breast Surgery

This study aims to compare single level serratus block versus bilevel serratus block with and without dexmedetomidine in cancer patients undergoing modified radical mastectomy for breast cancer regarding pain control and possible side effects.

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Key information

Conditions

Analgesia Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Walaa Y Elsabeeny

Cairo, Cairo Governorate, 11796, Egypt

Location status: Recruiting

Location contact

Walaa Y Elsabeeny, MD

CONTACT

[email protected]

+201007798466

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients scheduled for modified radical mastectomy,
  • Age 18-65 years,
  • ASA I-II

Exclusion criteria

  • patient refusal,
  • coagulation defects,
  • abnormal kidney or liver functions,
  • local infection at site of injection.

Treatment and study plan

Single level serratus anterior plane block

Procedure

Serratus anterior plane block with local anesthetics at the third rib

Single level serratus anterior plane block with dexmedetomidine

Procedure

Serratus anterior plane block with local anesthetics and dexmedetomidine at the third rib

Bilevel serratus anterior plane block

Procedure

Serratus anterior plane block with local anesthetics at the third and fifth rib

Bilevel serratus anterior plane block with dexmedetomidine

Procedure

Serratus anterior plane block with local anesthetics and dexmedetomidine at the third and fifth rib

Primary outcomes

  1. First time to receive analgesia

    Time frame: First 24 hours postoperatively

    first time to receive morphine analgesia in hours

  2. Total analgesic requisite

    Time frame: First 24 hours postoperatively

    total amount of morphine consumption in the first 24 hours postoperatively in mg

Secondary outcomes

  1. Pain scores

    Time frame: First 24 hours postoperatively

    pain scores will be assessed using Visual Analogue Scale on a sale from 0 to 10 with 0 meanung no pain and 10 meaning severe pain

  2. Side effects

    Time frame: First 24 hours postoperatively

    nausea and vomiting and hematoma at site of injection

  3. Perioperative heart rate values

    Time frame: First 24 hours

    heart rate values in the form of beat per minute in the perioperative period including preoperative, intraoperative and postoperative

  4. Mean arterial blood pressure

    Time frame: First 24 hours

    Mean arterial blood pressure values in the form mmHg in the perioperative period including preoperative, intraoperative and postoperative

Study contacts

Contact information is provided by the study sponsor or research team.

Nahla N Shehab, MD

CONTACT

[email protected]

01221682808 ext. +2

Walaa Y Elsabeeny, MD

CONTACT

[email protected]

201007798466 ext. +2

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Official study title

Efficacy of Single Level Versus Bilevel Serratus Anterior Plane Block With Dexmedetomidine During Breast Cancer Surgery

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
May 5, 2022
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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