Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06831253

Efficacy of Platelet-Rich Plasma Injection in Dry Eye Syndrome

The investigatror wants to show the efficacy of Platelet-Rich Plasma injection in lacrimal gland to restore the lacrimal secretion in patients presenting aqueous deficiency reponsible for severe dry eye syndrome.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Severe Dry Eye Syndromes Dry Eye Syndromes Eye Diseases Lacrimal Apparatus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Nice

Nice, Site Principal Investigator, 06000, France

Location status: Recruiting

Location contact

Jean Philippe Grosse, Dr

CONTACT

0492034702

About this study

injections in lacrimal gland four times during the study for each patient

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Platelet counts, and clotting factors in the standarts
  • Presenting with severe dry keratoconjunctivitis diagnosed by an ophthalmologist

Exclusion criteria

  • Patients with significant fibrosis of the conjunctival portion of the lacrimal gland
  • Patients with complete stenosis of both lacrimal meatus in the treated eye

Treatment and study plan

injections of Platelet-Rich Plasma in lacrimal gland

Other

injections of Platelet-Rich Plasma in lacrimal gland

Primary outcomes

  1. To compare the lacrimal secretion after 4 monthly injections of PRP into the lacrimal gland

    Time frame: week 16

    Schirmer I test score between 0mm and more 20mm

Secondary outcomes

  1. To compare the different clinical follow-up parameters of qualitative dry ocular syndrome and quantitative after 4 monthly injections of PRP into the lacrimal gland

    Time frame: week 16

    Ocular Surface Diseases Index (OSDI) a scale of 0 to 100

Study contacts

Contact information is provided by the study sponsor or research team.

Doctor Jean Philippe GROSSE, Dr

CONTACT

[email protected]

04.92.03.47.02

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Efficacy of Restoration of Lacrimal Secretion After Injection of Platelet-Rich Plasma (PRP) Into the Lacrimal Gland in Severe Dry Eye Syndromes (ReLIPSSO)

Acronym: ReLIPSSO

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 18, 2025
Registry last updated
Mar 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.