Efficacy of Paper-based Cognitive Training in Vietnamese Patients With Early Alzheimer's Disease

Inclusion criteria

• For patient:

• Diagnosis of Probable Alzheimer's Disease per DSM-5 criteria;
• In the early stage of AD (MMSE from 20 to 25);
• Age from 60 - 80 years old;
• Had greater than 5 years of formal education.
• For Caregiver:

• Members (including, but not limited to partners, children, relatives, lived-in helper of the patient) that are important for care delivery and provide care-related tasks (eg personal care, eating, cooking, cleaning) and everyday decision making to the patients. They are not required to live together or spend a specific amount of time with the patients;
• Older than 18 years of age;
• Possess adequate Vietnamese language skills and no cognitive impairment to conduct interview and evaluation

Exclusion criteria

• For patient:

• Patients with concomitant diseases (heart failure, kidney failure, liver failure or thyroid diseases) that affect cognitive functions;
• Diagnosed with significant neurologic disease other than AD (Parkinson's disease, multi-infarct dementia, schizophrenia, history of significant head trauma followed by persistent neurologic defaults, …), major depression within the past 1 year, or taking psychoactive medications (antidepressants with significant anticholinergic side effects, neuroleptics, chronic anxiolytics or sedative hypnotics, etc) within the past 1 month;
• Having major visual, auditory, reading, or writing impairments;
• Patients and/or caregivers who decline to participate.
• For cargiver:

• Having subjective complaints of cognitive impairment prevents them from understanding the instruction from the research team;
• Having significant visual, auditory, reading, or writing impairments;
• Caregivers who decline to participate