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Completed

NCT Number: NCT03163680

Efficacy of Low Dose of Proton Pump Inhibitor in Treatment Bleeding Ulcers

Determining the efficacy of low dose of PPI in management acute peptic ulcer bleeding

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Key information

Conditions

Gastroduodenal Ulcer Digestive System Diseases Duodenal Diseases Gastrointestinal Diseases Gastrointestinal Hemorrhage Hemorrhage Intestinal Diseases Marginal Ulcer Pathologic Processes Pathological Conditions, Signs and Symptoms Peptic Ulcer Peptic Ulcer Hemorrhage Stomach Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Damascus Hospital

Damascus, +963, Syria

About this study

Determining the efficacy of low dose meaning 40 mg of omeprazole twice in management acute peptic ulcer bleeding

Who can participate

Only the study team can determine whether someone qualifies for participation.

Criteria:

Inclusion criteria

High risk ulcers defined according to the Forrest classification With respect to high-risk stigmata, active bleeding was defined as a continuous blood spurting (Forrest IA) oozing (Forrest IB) from the ulcer base. A non-bleeding visible vessel at endoscopy was defined as a discrete protuberance at the ulcer base(Forrest IIA).

An adherent clot was one that was resistant to forceful irrigation or suction (Forrest IIB).

Exclusion criteria

ulcer was malignant non ulcerative bleeding such as angiodysplasia , a Mallory-Weiss tear

Treatment and study plan

Omeprazole 40 MG

Drug

Omperazole 40 mg twice daily

Primary outcomes

  1. Morality

    Time frame: within 1 week

    Determination of mortality rate from ulcer bleeding

Secondary outcomes

  1. Rebleeding

    Time frame: within 1 week

    Determination of the percentage of the return of bleeding represented by recurrent melena (black, tarry stool) or recurrent Hematemesis or coffee-ground emesis or recurrent hematochezia after begin treatment

  2. need for surgery

    Time frame: within 1 week

    Determine the Surgery rate for treatment Bleeding ulcers within a week

  3. Length of hospital stay

    Time frame: within 1 month

    Determining the length of stay in the hospital

  4. Blood transfusions

    Time frame: within 1 week

    number of transfusion blood unites during admission

Sponsors and collaborators

Lead sponsor

Damascus Hospital

Other

Registry information

Official study title

Efficacy of Low Dose of Proton Pumb Inhabitor in Treatment Upper Gastrointestinal Bleeding

Important dates

Study start
2012
Primary completion
2018
Study completion
2018
First posted
May 23, 2017
Registry last updated
Jul 10, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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