Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers

In order to assess the extent of healing of the biopsy sites, a 12-point scale was developed and validated.

After all of the procedures were complete, this scale was used to measure the effects of the study drugs on the healing of the biopsy-induced ulcers.

Inclusion criteria

• Signed informed consent
• Age 18-75
• Use of appropriate form of birth control for women of childbearing potential.

Exclusion criteria

• H pylori infection
• Use of NSAIDs within 2 weeks prior to start of enrollment
• Use of antacids or H-2 blockers within 2 weeks of enrollment
• Use of PPIs within 30 days of enrollment
• Corticosteroid use within 60 days of enrollment
• History of a previous ulcer
• Diagnosis of a bleeding diathesis or use of warfarin within 60 days of enrollment
• Use of cigarettes within 6 months of enrollment
• Consumption of >3 alcoholic beverages per day
• Hypersensitivity or allergy to NSAIDs, clopidogrel, or corn starch, or any contraindications to ingesting those substances
• The presence of an ulcer at a baseline endoscopy
• Endoscopically severe gastritis or duodenitis baseline endoscopy
• Moderate or severe inflammation located within the duodenal bulb or within 2cm of the pyloric channel at a baseline endoscopy
• Any gastroduodenal tumor.