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NCT Number: NCT06753448

Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty

The goal of this clinical trial is to find out the efficacy of diosmin and hesperidin on postoperative early rehabilitation after primary total knee arthroplasty. The main questions it aims to answer are:

Does diosmin and hesperidin combined drug decreases the lower extremity swelling, pain and increases the range of motion after primary total knee arthroplasty surgery compared to standard therapy group? Does diosmin and hesperidin combined drug decreases inflammation after total knee arthroplasty surgery.

Participants will take diosmin and hesperidin in addition to standard therapy for 14 days after total knee arthroplasty surgery. Lower extremity swelling, pain and range of motion of the patients will be recorded in every visit.

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Key information

Conditions

Total Knee Arthroplasty Agnosia Cardiovascular Diseases Inflammation Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms Vascular Diseases Venous Insufficiency Venous Insufficiency of Leg

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Etlik City Hospital

Ankara, Yenimahalle, 06070, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent unilateral primary total knee replacement surgery
  • Patients who are functionally ASA 1, ASA 2 or ASA 3.

Exclusion criteria

  • Patients >80 years or <18 years of age
  • Patients with liver insufficiency
  • Patients with allergy to diosmin or hesperidin
  • Patients which are not capable to communicate

Treatment and study plan

Diosmin and Hesperidin Combination

Drug

Participants will take diosmin and hesperidin combination for 14 days after total knee replacement surgery.

Primary outcomes

  1. Lower extremity swelling

    Time frame: From enrollment to the end of the treatment at 2 weeks

    Lower extremity swelling is measured by measuring extremity diameters from 3 points (below patella, patella and above patella) and noted. Then percentage of increment or decrement of diameters is measured.

Secondary outcomes

  1. Pain

    Time frame: From enrollment to the end of the treatment at 2 weeks

    The Visual Analog Scale is used to describe patients' pain. It is a scale that describes pain by giving numbers from 0 to 10. 0 means no pain and 10 means extreme pain.

  2. Range of motion

    Time frame: From enrollment to the end of the treatment at 2 weeks

    Knee range of motion is measured with goniometer.

  3. Blood C-reactive protein value as an inflammotory marker

    Time frame: From enrollment to the end of the treatment at 2 weeks

  4. Blood erythrocyte sedimentation rate as an inflammotory marker

    Time frame: From enrollment to the end of the treatment at 2 weeks

  5. Blood neutrophil/lymphocyte rate as an inflammatory marker

    Time frame: From enrollment to the end of the treatment at 2 weeks

  6. Panimmune value (neutrophil x platelet x monocyte / lymphocyte) as an inflammatory marker

    Time frame: From enrollment to the end of the treatment at 2 weeks

  7. The systemic immune-inflammation index (neutrophils × platelets/lymphocytes) as an inflammatory marker

    Time frame: From enrollment to the end of the treatment at 2 weeks

Sponsors and collaborators

Lead sponsor

Ankara Etlik City Hospital

Other Gov

Registry information

Official study title

Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Primary Total Knee Arthroplasty

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 31, 2024
Registry last updated
Jul 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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