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NCT Number: NCT06124170

Improved Pain Management in Knee Osteoarthritis-related Surgeries

In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.

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Key information

Conditions

Knee Osteoarthritis Agnosia Arthritis High Tibial Osteotomy Joint Diseases Musculoskeletal Diseases Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Osteoarthritis Osteoarthritis, Knee Pain Management Pathological Conditions, Signs and Symptoms Perceptual Disorders Rheumatic Diseases Signs and Symptoms Total Knee Arthroplasty Unicompartmental Knee Arthroplasty

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sichuan Provincial People's Hospital

Chengdu, Sichuan, 610072, China

About this study

We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • first knee surgery were 50-80 years old had complete clinical and follow-up data

Exclusion criteria

  • American Society of Anesthesiologists Physical Status grade≥4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration

Treatment and study plan

Preoperative pain managment

Procedure

propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery

Intraoperative pain managment

Procedure

Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;

Postoperative pain managment

Procedure

The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

Primary outcomes

  1. visual analogue score (VAS)

    Time frame: 24 hours after surgery

    visual analogue score (VAS)

  2. visual analogue score (VAS)

    Time frame: 72 hours after surgery

    visual analogue score (VAS)

Secondary outcomes

  1. Quadriceps muscle strength

    Time frame: 24 hours after surgery

    Quadriceps muscle strength

  2. Quadriceps muscle strength

    Time frame: 72 hours after surgery

    Quadriceps muscle strength

  3. Scope of activities to knee joint

    Time frame: 24 hours after surgery

    Scope of activities to knee joint

  4. Scope of activities to knee joint

    Time frame: 72 hours after surgery

    Scope of activities to knee joint

Other outcomes

  1. Self-Rating Anxiety Scale (SAS)

    Time frame: 24 hours after surgery

    Self-Rating Anxiety Scale (SAS)

  2. Self-Rating Anxiety Scale (SAS)

    Time frame: 72 hours after surgery

    Self-Rating Anxiety Scale (SAS)

  3. Self-Rating Depression Scale (SDS)

    Time frame: 24 hours after surgery

    Self-Rating Depression Scale (SDS)

  4. Self-Rating Depression Scale (SDS)

    Time frame: 72 hours after surgery

    Self-Rating Depression Scale (SDS)

Sponsors and collaborators

Lead sponsor

Peng Liu

Other

Registry information

Official study title

Evaluating the Effectiveness of Continuously Improved Pain Management in Knee Osteoarthritis-related Surgeries

Important dates

Study start
2016
Primary completion
2022
Study completion
2023
First posted
Nov 9, 2023
Registry last updated
Nov 9, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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