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NCT Number: NCT05851768

Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain

Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.

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Key information

Conditions

Analgesia Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 18 to 65 years.
  • Male and female sexes.
  • ASA I-II.,III
  • Cancer patients undergoing thoracotomy incisions
  • Body mass index (BMI) from 18.5 to 30 kg/m2

Exclusion criteria

  • Patient refusal
  • Known allergy to any of the used drugs
  • Low platelet count, any coagulation defect

Treatment and study plan

Bupivacaine

Drug

Bupivacaine 0.25%

Bupivacaine + Magnesium

Drug

Bupivacaine 0.25% + Magnesium

Bupivacaine + Dexmedetomidine

Drug

Bupivacaine 0.25% + Dexmedetomidine

Primary outcomes

  1. Total postoperative morphine consumption

    Time frame: First 24 hours postoperatively

    Total dose of morphine needed postoperatively in the first 24 h

Secondary outcomes

  1. Time to first postoperative rescue analgesia.

    Time frame: First 24 hours postoperatively

    Time to first postoperative rescue analgesia.

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed A Mohamed, MD

CONTACT

[email protected]

01272222923 ext. +2

Walaa Y Elsabeeny, MD

CONTACT

[email protected]

01007798466 ext. +2

Sponsors and collaborators

Lead sponsor

National Cancer Institute, Egypt

Other

Registry information

Official study title

Analgesic Efficacy of Adding Dexmedetomidine VS Magnesium Sulphate as Adjuvants With Bupivacaine in Ultrasound-guided Erector Spinae Plane Block for Post Thoracotomy Pain

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
May 10, 2023
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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