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Completed

NCT Number: NCT03000699

Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction

The purpose of this study is to determine whether computer bias modification for interpretation bias (CBM-I) is effective in the reduction of suicidal ideation in substance use disorders.

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Key information

Conditions

Substance Dependence Behavior Behavioral Symptoms Chemically-Induced Disorders Depression Mental Disorders Self-Injurious Behavior Substance-Related Disorders Suicidal Ideation Suicide

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre for Addiction and Mental Health

Toronto, Ontario, M5T 1R8, Canada

About this study

Eighty-eight adult inpatients completing residential treatment in the Addictions Services at the Centre for Addiction and Mental Health (CAMH) will be randomized to receive CBM-I daily for one week, adjunct to the residential psychosocial treatment or to an assessment-only control condition. Participants will complete clinical measures consisting of interviews and questionnaires measuring suicidal ideation, hopelessness, depression, negative affect, and interpretation biases before, during and after treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Exhibit moderate suicide risk or greater
  • Be enrolled in the Addictions Services inpatient program
  • Fluent in reading English
  • Capacity to give informed consent

Exclusion criteria

  • A lifetime diagnosis of a psychotic or bipolar disorder
  • Significant neurological disorder or psychical illness likely to interfere with participation
  • Psychotropic medication changes within the past two weeks

Treatment and study plan

Cognitive Bias Modification

Behavioral

Training paragraphs describe scenarios designed to be ambiguous at the outset and to resolve in a positive direction, with the intention of establishing a learning contingency between the ambiguity at the beginning of the scenario and the positive resolution that becomes clear towards the end of the statement.

Primary outcomes

  1. Columbia-Suicide Severity Rating Scale, Screen Version (C-SSRS)

    Time frame: Seven days

    This scale quantifies the severity of suicidal ideation and behaviour.

Secondary outcomes

  1. Beck Hopelessness Scale (BHS)

    Time frame: Seven days

    This questionnaire assesses thoughts and emotions associated with the future.

  2. Beck Depression Inventory II (BDI-II)

    Time frame: Seven days

    This questionnaire assesses severity of depressive symptoms and cognitions.

  3. Positive and Negative Affect Schedule (PANAS)

    Time frame: Seven days

    This questionnaire assesses current positive and negative mood

  4. Scrambled Sentences Tests

    Time frame: Seven days

    This computer test will be used as an implicit measure of negative interpretation bias.

Sponsors and collaborators

Lead sponsor

Centre for Addiction and Mental Health

Other

Collaborators

  • American Foundation for Suicide Prevention

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Dec 22, 2016
Registry last updated
Jan 30, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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