Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye

Stevens-Johnson syndrome patients in chronic stage who have dry eys symptoms and signs will be treated with 0.05%cyclosporin ophthalmic emulsion(Restasis)twice a day for 6 months, compare results at 0,2,4,6 months include dry eye symptoms, corneal staining (Fluorescein, Rose Bengal), Schirmer I,FCT and impression cytology

Inclusion criteria

• Males or females, of legal age of consent
• Patient with Stevens-Johnson syndrome in chronic stage or has symptoms more than 3 months and has dry eye symptoms
• Dry eye symptoms are defined as

• has dry eye symptom everyday for more than 3 months
• has foreign body sensation frequently
• use tear substitutes more than 3 times per day
• Tear test shaw abnormalities at least 1 of 2 of following:

• Schirmer test without anesthesia is not more than 5 millimeters in 5 minutes
• Fluorescein clearance test at first 10 minutes is not more than 3 millimeters and has at least 1 of 3 of the following:

2.1.Rose Bengal score is not less than 4 2.2.Fluorescein stain at cornea 2.3.Impression cytology is consistent to dry eye

• Patent punctum

Exclusion criteria

• Age < 18 years old
• Patients with Steven Johnson syndrome without dry eye
• Patients used oral cyclosporine or anticholinergic drug within past 2 months
• Patients with HIV or immunocompromise status
• Patients with active ocular infections and patients with a history of herpes keratitis
• Patients with known or suspected hypersensitivity to any of the ingredients in the formula (cyclosporine, glycerin, castor oil, polysorbate 80, carbomer 1342)
• Female patients are pregnant or nursing