Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Inclusion criteria

• Patients of both sexes.
• Aged between 40 and 85 years old.
• Diagnosed with osteoarthritis through clinical radiological examination.
• Joint pain equal to or less than 75 points on the KOOS (pain).
• Radiological severity grades 1, 2, and 3 according to the Ahlbäck scale.
• Indication for intra-articular PRP infiltration.
• Body Mass Index values between 20 and 35.
• Negative serological tests for syphilis, HIV, HBV, and HCV.
• Possibility of observation during the follow-up period.
• Signature of informed consent.

Exclusion criteria

• Body mass index >35
• Diagnosed polyarticular disease.
• Previous arthroscopy in the last year.
• Severe mechanical deformity.
• Intra-articular hyaluronic acid injection in the last 12 months.
• Intra-articular corticosteroid or PRP injection in the last 6 months.
• Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
• Anemia or other hematological disorders.
• Positive serological tests for SYPHILIS, HIV, HBV, and HCV.
• Undergoing immunosuppressive treatments.
• Poorly controlled diabetes mellitus.
• Patients allergic to paracetamol.
• Pregnancy or breastfeeding.