Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.

Inclusion criteria

• Ages 40-70 years;
• cf-PWV was abnormally elevated and above the upper limit of its age-and blood-pressure matched reference range;
• Systolic Blood Pressure < 160 mmHg and ≥ 140 mmHg or Diastolic BP < 100 mmHg ≥ 90mmHg;
• Signed informed consent.

Exclusion criteria

• Consumption of foods or medications containing high levels of NAD+, NR, NAM, NMN, or niacin-related components (including Vitamin B3 and natural health products) within 3 months prior to screening；
• History of major cardiovascular or cerebrovascular events, including myocardial infarction, angina, stroke, or hospitalization for arterial revascularization；
• Systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg；
• Diagnosis of malignant tumor；
• Known allergy or history of severe adverse reactions to Coenzyme I injection or any of its components；
• History of severe allergies or infusion reactions；
• Women who are pregnant, breastfeeding, or planning pregnancy；
• Severe hepatic or renal dysfunction: ALT or AST > 5 times the upper limit of normal; glomerular filtration rate ≤ 30 mL/min/1.73 m²；
• Concurrent participation in another clinical trial without completion of the follow-up period；
• Other conditions deemed by the investigator as unsuitable for inclusion, such as psychiatric or psychological disorders.