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NCT Number: NCT07727772

Vascular Aging and Acute Kidney Injury After Cardiac Surgery

This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.

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Key information

Conditions

Acute Kidney Injury Cardiac Surgery Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Renal Insufficiency Urogenital Diseases Urologic Diseases Vascular Aging

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Acute kidney injury is a common postoperative complication after cardiac surgery and is associated with adverse short-term and long-term outcomes. Vascular aging may reflect systemic vascular dysfunction, impaired vascular compliance, endothelial dysfunction, and reduced renal perfusion reserve, which may increase susceptibility to postoperative acute kidney injury.

This prospective observational cohort study will include adult patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Perioperative vascular aging-related indicators will be collected according to the study protocol. These indicators may include noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. Postoperative renal function will be monitored after surgery, and acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria.

The primary objective is to investigate the association between multidimensional vascular aging markers and the occurrence and severity of postoperative acute kidney injury. Secondary analyses may evaluate the relationships between vascular aging burden and postoperative clinical outcomes, including intensive care unit stay, hospital stay, and other postoperative complications when available. This is an observational study, and no treatment, surgical procedure, or perioperative management strategy will be assigned by the study protocol.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aged 18 years or older.
  • Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
  • Patients who are able to provide written informed consent.
  • Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.

Exclusion criteria

  • Patients younger than 18 years.
  • Patients with preoperative end-stage renal disease or maintenance dialysis.
  • Patients who are unable to complete the study-specified vascular aging assessment.
  • Patients who decline participation or withdraw informed consent.

Treatment and study plan

Multidimensional Vascular Aging Assessment

Other

Perioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants.

Primary outcomes

  1. Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery

    Time frame: From the date of surgery to postoperative day 7

    Postoperative acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria based on postoperative renal function changes. The outcome will be recorded as the occurrence of acute kidney injury during the postoperative 7-day period.

Secondary outcomes

  1. Severity of Postoperative Acute Kidney Injury

    Time frame: From the date of surgery to postoperative day 7

    The severity of postoperative acute kidney injury will be classified according to predefined staging criteria during the postoperative 7-day period.

Study contacts

Contact information is provided by the study sponsor or research team.

F Hu

CONTACT

[email protected]

+8615162614385

Sponsors and collaborators

Lead sponsor

Nanjing First Hospital, Nanjing Medical University

Other

Registry information

Official study title

Multidimensional Assessment of Vascular Aging and Its Association With Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 27, 2026
Registry last updated
Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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