Effects os Physiotherapeutic Rehabilitation on Function Autonomic and Inflammatory in Patients With Long Covid

Introduction: Long COVID is characterized by persistent symptoms that persist for weeks or months after the acute phase of infection, with a significant impact on the cardiovascular and autonomic systems. Objectives: This study aims to evaluate the effects of a physiotherapeutic rehabilitation protocol on cardiovascular autonomic modulation and on inflammatory and cardiac biomarkers in patients with Long COVID. Methodology: This is a controlled clinical trial, carried out in a cardiorespiratory rehabilitation outpatient clinic, involving individuals with a clinical diagnosis of Long COVID undergoing a protocol of 20 aerobic, anaerobic and respiratory rehabilitation sessions. Heart rate variability (HRV) variables will be analyzed using linear and non-linear methods, in addition to serum levels of CKMB, LDH, ferritin and C-reactive protein. Expected results: Rehabilitation is expected to provide an improvement in autonomic function and a reduction in inflammatory and cardiac markers, contributing to the understanding of the pathophysiological mechanisms of Long COVID and helping to propose evidence-based therapeutic strategies.

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Key information

Conditions

Long COVID COVID-19 Cardiac Biomarkers Chronic Disease Coronaviridae Infections Coronavirus Infections Disease Attributes Heart Rate Variability (HRV) Infections Inflammatory Biomarkers Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Post-Acute COVID-19 Syndrome Post-Infectious Disorders RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

20 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

both sexes
aged 20 and 59 years
clinical evaluation and undergoing clinical follow-up of Post COVID-19.
least one persistent COVID-19-related symptom.

Exclusion criteria

incomplete data.
presence of a pacemaker
use of antihypertensive drugs that alter HRV
persistent pulmonary alterations
persistent desaturation
anaemia or presence of reinfection.

Treatment and study plan

physiothreapy protocol

Other

Aerobic training (treadmill or exercise bike) for 15 minutes, anaerobic training at the weight training station, performing exercises for the upper limbs (bench press and front pull) and lower limbs (180º leg press and extension chair) with weight determined by the 1 Repetition Maximum (1RM) test, performing 3 sets of 12-15 repetitions (depending on the session) and respiratory muscle training using POWERbreathe (30-40% of the MIP performed in the manovacuometry test).

Primary outcomes

Autonomic Modulation

Time frame: Before and afther the intervention 3 months.

cardiofrequency meter

Secondary outcomes

Inflammation

Time frame: Before and the afther 3 months

the cardiac and inflammatory biomarkers, creatine phosphokinase isoenzyme MB (CKMB) associated with lactate dehydrogenase (LDH) and ferritin can be analysed.

Study contacts

Contact information is provided by the study sponsor or research team.

Luiz Magno Falcão, Research and coordinator

CONTACT

[email protected]

+5591982379488

Sponsors and collaborators

Lead sponsor

Universidade do Estado do Pará

Other

Registry information

Official study title

Effects os Physiotherapeutic Rehabilitation on Cardiovascular Autonomic Modulation and Biomarkers Inflammatory and Cardiac Conditions in Patients With Long Covid

Acronym: LongCovidRehab

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jul 1, 2025
Registry last updated: Jul 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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