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Completed

NCT Number: NCT02163668

Effects of Yoga on Bone Metabolism in Premenopausal Women

This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years. The style of Yoga used was power Yoga that involved postures with a jumping component. The investigators hypothesized that the Yoga intervention would result in beneficial improvements in bone turnover markers, by increasing the bone formation marker and decreasing the bone resorption marker.

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Key information

Conditions

Bone Health Bone Diseases Bone Diseases, Metabolic Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Osteoporosis

Age range

35 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Department of Health and Exercise Science, University of Oklahoma

Norman, Oklahoma, 73019, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • participants had not been engaged in resistance training or in Yoga exercise for at least 12 months prior to the study
  • did not have chronic back or joint problems or cardiovascular disease
  • not taking antihypertensive drugs or any medication that affects bone density
  • not taking hormonal contraception
  • they self-reported having regular menstrual cycles.

Exclusion criteria

  • body weight more than 300 pounds

Treatment and study plan

yoga group

Other

8 months of Yoga training

Primary outcomes

  1. Change in bone mineral density from baseline to 8 months

    Time frame: pre and post 8 months training

  2. change in bone turnover markers

    Time frame: pre and post 8 month intervention

  3. change in tibia bone characteristics

    Time frame: pre and post 8 month intervention

    changes in volumetric bone mineral density and bone strength of the non-dominant tibia assessed by peripheral Quantitative Computed Tomography (pQCT)

  4. Changes in muscular strength

    Time frame: pre and post 9 month intervention

    Isotonic 1 repetition maximum (1RM) for 4 lower body and 2 upper body resistance exercises

  5. Change in arterial compliance

    Time frame: pre and post 8 month interventon

    Arterial compliance of the large and small arteries was assessed using Pulse Contour analysis.

  6. Change in Insulin-like Growth Factor-1 (IGF-I) and Insulin-like Growth Factor BP3 (IGFBP3)

    Time frame: pre and post 8 month intervention

Secondary outcomes

  1. Daily Calcium intake

    Time frame: pre and post 8 month intervention

    Calcium intake is a potential confounding variable. Participants were encouraged to increase their calcium intakes if found to be low before the intervention began.

  2. Menstrual History

    Time frame: pre and post 8 month intervention

    This information was used to monitor menstrual characteristics to ensure they were still premenopausal at the post test.

  3. Dietary intake

    Time frame: At baseline at the same time as other outcomes, about 2 weeks before the beginning of the yoga training

    Three day dietary logs were recorded by participants before the exercise intervention. They were analyzed for caloric intake and nutrient composition using the Diet Analysis Plus 9 software.

  4. Change in physical activity levels

    Time frame: pre and post 8 month intervention

    Physical activity levels estimated by the bone-specific physical activity (PA) questionnaire to monitor their PA outside of the intervention

  5. Change in body composition

    Time frame: pre and post 8 month intervention

Sponsors and collaborators

Lead sponsor

University of Oklahoma

Other

Registry information

Official study title

Effects of an 8-month Yoga Intervention on Bone Metabolism in Healthy Middle-aged Premenopausal Women: A Randomized Controlled Study

Important dates

Study start
2009
Primary completion
2010
Study completion
2012
First posted
Jun 16, 2014
Registry last updated
Jun 16, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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