Skip to main content
OpenTrials
Completed

NCT Number: NCT00202098

Effects of Variable Ventilation on Respiratory System of Acute Respiratory Distress Syndrome (ARDS) Patients

The purpose of this study is to determine the effects of variable ventilation on respiratory system of patients affected by acute respiratory distress syndrome.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

ARDS

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Policlinico Hospital

Milan, Italy

About this study

In this interventional study we want to evaluate the effect of Variable ventilation (1) in patients with ARDS. Patients will be mechanically ventilated with Variable Ventilation (3 step with increased level of variability) and "traditional" CMV, for a total of 4 step. Each step lasts in 60 minutes. During this period we will record the gas exchange parameters and the mechanics of the respiratory system.

  • Arold S, Mora R, Lutchen K, et al. Variable ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury. Am J Resp Crit Care Med 2000; 165: 366-71.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with ARDS criteria

Exclusion criteria

  • Age less than 18 years
  • Severe haemodynamic instability
  • Patients with clinical or instrumental evidence of flow-limitation (i.e., PEEPi)

Treatment and study plan

Variable ventilation

Procedure

Patients will be mechanically ventilated with Variable Ventilation (3 step with increased level of variability) and "traditional" CMV, for a total of 4 step. Each step lasts in 60 minutes. During this period the investigators will record the gas exchange parameters and the mechanics of the respiratory system.

Primary outcomes

  1. Gas exchange and respiratory mechanics

    Time frame: within the first 60 minutes from the ventilatory change

Sponsors and collaborators

Lead sponsor

Policlinico Hospital

Other

Registry information

Official study title

Effects of Variable Ventilation on Respiratory System of ARDS Patients

Important dates

Study start
2005
Primary completion
2013
Study completion
2015
First posted
Sep 20, 2005
Registry last updated
Mar 19, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.