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Completed

NCT Number: NCT01983397

Effects of Two Physical Exercise Protocols on Cognition and Physical Performances in Elderly Over 80 Years

The purpose of this study is to compare the effects of different trainings on cognition and physical performances in elderly over 80 years.

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Key information

Conditions

Sedentary Behavior Motor Activity Sedentary Behavior

Age range

80 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidade Federal de São Carlos

São Carlos, São Paulo, 13565-905, Brazil

About this study

Purpose: To compare the effects of 16-week multicomponent and resistance trainings on cognition and physical performances related to falls in oldest old people living in community; to analyze the same variables after 6-week detraining. Method: We conducted a randomized controlled trial with 69 community elderly over 80 years, sedentary and without cognitive disorder. Participants were allocated to control, multicomponent training or resistance training group. The multicomponent group performed a protocol involving warm-up, aerobic, strength, balance and cool-down exercises. The resistance group underwent to strength exercises using six machines: leg press, chest press, calf, back extension, abdominal and rowing. The control group did not perform any intervention. The trainings had progressive intensity, lasted 16 weeks and included three 1-hour sessions per week. The participants were evaluated at baseline, at the end of 16-week training and at 6-week detraining. The assessment consisted of anamnesis, depression (Geriatric Depression Scale), cognition (Montreal cognitive assessment), dual task walking (associated to cognitive and motor tasks), balance (unipedal and tandem tests), strength of lower limbs (sit-to-stand test) and history of falls. For statistical analysis by intention to treat, we adopted a significance level of α=0.05.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age between 80 and 95 years old
  • live in community
  • sedentary lifestyle
  • ability to walk without help from another person with/without aid walking

Exclusion criteria

  • any cardiovascular or infectious comorbidity described in the absolute contraindications of the Physical Activity Readiness Medical Examination
  • Relative contraindications of cognitive, neurological and/or musculoskeletal comorbidities which make participation in protocols impossible
  • Score in mini-state examination mental below the cutoff score designated by education level.

Treatment and study plan

Multicomponent training

Other

The multicomponent training consisted of individuals subjected to a multicomponent exercise program: 5 minute warm up, 20 minutes of aerobic exercise, 15-20 minutes of strength exercises, 10 minutes of coordination, agility and balance exercises and 5 minute of cool-down.

Resistance training

Other

The resistance training was subjected to a strength training using weight machines adapted for elderly. The protocol followed three sets of 10 to 12 maximal repetitions, moderate speed (two seconds for the shortening phase and three seconds for the elongation phase) and one minute for rest interval between sets.

Primary outcomes

  1. Changes from baseline in lower limbs strength after 16 weeks of training and 6 weeks of detraining

    Time frame: Assessed at baseline, after 16 weeks of training and 6 weeks of detraining

    Lower limbs strength was assessed by 5 times sit-to-stand test.

  2. Changes from baseline in balance after 16 weeks of training and 6 weeks of detraining

    Time frame: Assessed at baseline, after 16 weeks of training and 6 weeks of detraining

    Balance was assessed by unipedal test and tandem test.

  3. Changes from baseline in dual task walking after 16 weeks of training and 6 weeks of detraining

    Time frame: Assessed at baseline, after 16 weeks of training and 6 weeks of detraining

    Dual task was assessed by Timed Up and Go test with a cognitive task (speak day of week in reverse order) and motor task (carry a cup of water).

  4. Changes from baseline in cognition after 16 weeks of training and 6 weeks of detraining

    Time frame: Assessed at baseline, after 16 weeks of training and 6 weeks of detraining.

    Cognition was evaluated by Montreal Cognitive Assessment.

Secondary outcomes

  1. Changes from baseline in number of falls after 16 weeks of training and 6 weeks of detraining

    Time frame: Assessed at baseline, during 16 weeks of training and 6 weeks of detraining.

    Presence of falls was assessed by falls calendar and phone calls.

  2. Changes from baseline in depression after 16 weeks of training and 6 weeks of detraining

    Time frame: Assessed at baseline, during 16 weeks of training and 6 weeks of detraining.

    Depression was assessed by abbreviated Geriatric Depression Scale.

Sponsors and collaborators

Lead sponsor

Universidade Federal de Sao Carlos

Other

Registry information

Official study title

Effects of Two Physical Exercise Protocols on Cognition and Physical Performances in Oldest Old: a Randomized Controlled Trial

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Nov 14, 2013
Registry last updated
Nov 14, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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