Effects of Two Hypocaloric Diets on Weight Loss

The investigators evaluated whether an energy-restricted protein diet with low glycaemic index carbohydrates and soluble fibers (LC-P-LGI) would be more effective than a conventional diet (LC-CONV) on weight-loss and related metabolic variables.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

25 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assistant pubique-hopitaux Paris

Paris, 75004, France

About this study

The subjects (9 men and 5 post-menopausal women) were randomly allocated, in a cross-over design, to two periods of 4 weeks of an energy restricted diet of 1200 kcal as either a conventional diet (LC- CONV) or a special energy restricted diet compensated by proteins (LC-P-LGI). The two nutritional periods were separated by a wash-out interval of 8 weeks. Before the start of the study, all subjects were instructed to maintain their usual lifestyle during the experimental period.Anthropometric parameters, glucose and lipid homeostasis and inflammatory markers were evaluated before and after each dietary period.Body fat and fat-free mass distributions were measured by a dual-energy X-ray absorptiometry (DXA, GE Lunar Prodigy Corporation, Madison, WI, USA) before and after each dietary period at the fasting state.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI 26 to 35 Kg/m2
25 to 60 years old
non diabetic subjects

Exclusion criteria

SGOT and SGPT >2.5x the normal
plasma glucose more than 1.26 g/l
hepatic or renal or cardiac failure

Treatment and study plan

LC-P-LGI diet

Other

a hypocaloric diet low in lipids (25%) which is compensated by proteins (35%) with no change in carbohydrate content.

LC-CONV

Other

4-week CONV period consisted in the subjects' consumption of 1200 Kcal/ day (25% protein, 31% lipids, 44% carbohydrates).

Sponsors and collaborators

Lead sponsor

Ceprodi S.A. Kot

Industry

Collaborators

Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France
Pierre and Marie Curie University

Registry information

Official study title

Effects of Two Hypocaloric Diets on Weight Loss and Inflammatory Markers

Important dates

Study start: 2007
Primary completion: 2007
Study completion: 2008
First posted: Mar 11, 2011
Registry last updated: Mar 11, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed