Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07041905

Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study

The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Pulp Exposure, Dental Deep Dental Caries Dental Pulp Diseases Dental Pulp Exposure Stomatognathic Diseases Tooth Diseases

Age range

15 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cukurova University

Adana, Turkey (Türkiye)

Location status: Recruiting

Location contact

Cukurova University Cukurova University Faculty of Dentistry

CONTACT

[email protected]

0322 338 73 30

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged ≥15 years with bilateral deep carious mature permanent teeth.
  • Positive vitality test (cold sensitivity).
  • No spontaneous pain or periapical radiolucency.
  • Willingness to attend 6- and 12-month follow-ups

Exclusion criteria

  • Uncontrolled systemic diseases Pregnancy or allergy to dental materials used Teeth with irreversible pulpitis (spontaneous pain, necrosis) Non-restorable teeth (fractures, extensive decay)

Treatment and study plan

Total caries removal

Procedure

Arm 1: "Total caries removal (complete excavation to hard dentin)"

Selective caries removal

Procedure

Partial removal leaving affected dentin near pulp.

Primary outcomes

  1. Early postoperative pain intensity (VAS) after total vs. selective excavation

    Time frame: first week

    The patient will be asked to rate his/her pain on day 1, 3 and 7 according to VAS

  2. dentin bridge formation

    Time frame: twelve months

    no dentin bridge formation is expected in selective caries cleaning, while dentin bridge formation will be observed radiologically in total cleaning

  3. pulp survival at twelve months

    Time frame: twelve months

    The pulp is expected to remain vital, with no percussion tenderness and no spontaneous pain

Study contacts

Contact information is provided by the study sponsor or research team.

Zehra Zehra Susgun Yıldırım, Principal investigator

CONTACT

[email protected]

0553 454 1123

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 27, 2025
Registry last updated
Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.