Sinop University
Sinop, Turkey (Türkiye)
Location contact
SEFA H HATIK, Asst. Prof.
CONTACT
SEFA H HATIK, Asst. Prof.
PRINCIPAL_INVESTIGATOR
Not Yet Recruiting
NCT Number: NCT07068698
Effects of Thumb Manipulation on Hand Grip Strength, Function, and Sensation
This randomized controlled study will aim to investigate the effects of thumb manipulation on hand grip strength, function, and sensation in healthy individuals. A total of 60 volunteers aged between 18 and 50 years will be recruited from Ortadağ Special Education and Rehabilitation Center. Participants will be randomly assigned to either a chiropractic manipulation group (n=30) or a control group (n=30), with an equal distribution of males and females in each group. The intervention group will receive thumb manipulation twice weekly for 4 weeks, while the control group will not receive any intervention. Outcome measures will include two-point discrimination (assessed with a discriminator), hand grip strength (measured using a dynamometer), pinch strength (evaluated with a pinch meter), and hand function (measured by the Duruöz Hand Index). Statistical analyses will be performed with a significance level set at p<0.05. It is expected that participants in the manipulation group will show greater improvements in all measured parameters compared to the control group, suggesting a positive effect of thumb manipulation on hand-related sensorimotor functions in healthy individuals.
Not Yet Recruiting
Trial opening soon.
Get NotifiedKey information
Conditions
Age range
18 year–50 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
About this study
This study will be designed as a randomized controlled clinical trial to evaluate the effects of thumb manipulation on hand grip strength, functional ability, and sensory parameters in healthy individuals. Sixty volunteers aged between 18 and 50 years will be recruited from Ortadağ Special Education and Rehabilitation Center. After anthropometric assessments, participants will be randomly assigned into two groups: a chiropractic manipulation group (n=30) and a control group (n=30), with equal numbers of males and females in each group.
The intervention group will undergo thumb manipulation performed by a trained physiotherapist twice a week for four weeks. The control group will not receive any intervention during this period. All participants will be evaluated at baseline, at the end of the 4-week intervention, and at follow-up.
Outcome measures will include:
Hand grip strength, measured using a hand dynamometer, Pinch strength, assessed with a pinch meter on the thumb, index, and middle fingers, Two-point discrimination, evaluated on the thumbs using a discriminator tool, Hand function, assessed using the Duruöz Hand Index. This study will aim to determine whether a short-term thumb manipulation protocol can lead to measurable improvements in sensory and motor functions of the hand in a healthy population. The findings may provide a basis for future research involving clinical populations with hand dysfunction.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Aged between 18 and 50
- Willing to participate in the study
- Have signed the informed consent form
- Able to use verbal and written communication skills
Exclusion criteria
- Having contraindications that may prevent manipulation
- Having a history of congenital or acquired orthopedic or neurological conditions affecting the upper extremity
- Having a history of rheumatological diseases
- Having a history of trauma or surgery affecting the upper extremity
Treatment and study plan
Thumb Manipulation
OtherThis intervention consists of chiropractic manipulation techniques applied specifically to the thumb joint. The manipulation will be performed by a trained physiotherapist twice weekly for 4 weeks. The procedure aims to improve thumb joint mobility, hand grip strength, sensory function, and overall hand function. Each session includes standardized manual therapy maneuvers targeting the thumb's range of motion and soft tissue mobility without the use of any devices or medications. The intervention differs from other manual therapies by focusing solely on the thumb region.
Other names: Chiropractic Thumb Manipulation, Manual Thumb Mobilization
Primary outcomes
-
Duruoz Hand Index
Time frame: T0 (Baseline, before intervention), T1 (Week 2 of intervention), and T2 (Week 4, end of intervention
The Duruöz Hand Index is a validated self-reported questionnaire used to assess hand function and disability in daily activities. It includes 18 items covering various tasks such as dressing, hygiene, kitchen activities, and carrying objects. Each item is scored on a scale from 0 (no difficulty) to 5 (unable to perform), with higher scores indicating greater hand disability.
-
Two-Point Discrimination Test
Time frame: T0 (Baseline, before intervention), T1 (Week 2 of intervention), and T2 (Week 4, end of intervention)
The Two-Point Discrimination Test is used to evaluate sensory perception and tactile acuity. It measures the smallest distance at which two points of contact can be perceived as separate. In this study, the test will be applied to the thumb (right and left) using a standardized discriminator tool. Lower discrimination distances indicate better sensory perception. The test provides objective data on changes in cutaneous sensory function.
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Pinchmeter
Time frame: T0 (Baseline, before intervention), T1 (Week 2 of intervention), and T2 (Week 4, end of intervention)
Pinch strength will be measured using a standardized pinchmeter to assess lateral, palmar, and tip-to-tip pinch strength in the thumb, index, and middle fingers of both hands. The test will provide quantitative data on fine motor strength and thumb function. Higher values indicate increased pinch strength. The measurement will be used to evaluate the effect of thumb manipulation on hand function.
Study contacts
Contact information is provided by the study sponsor or research team.
OMER D KIZIL, PhD.
CONTACT
SEFA H HATIK, Asst. Prof.
CONTACT
Sponsors and collaborators
Lead sponsor
SEFA HAKTAN HATIK
Other
Registry information
Official study title
The Effects of Thumb Manipulation on Hand Grip Strength, Hand Function, and Sensory Parameters
Acronym: THUMBFUN
Important dates
- Study start
- 2025
- Primary completion
- 2025
- Study completion
- 2025
- First posted
- Jul 16, 2025
- Registry last updated
- Jul 16, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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