Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities

This study is being done to test the possible benefits of task-specific focused ankle training using the Ankle-Bot on subjects with Multiple Sclerosis who have "foot-drop." The study also compares the effectiveness of task-specific focused ankle training using the Ankle-Bot with conventional focused ankle therapy in improving the gait of subjects with MS.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Mobility Limitation Mononeuropathies Nervous System Diseases Neuromuscular Diseases Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Peroneal Neuropathies Signs and Symptoms

Age range

25 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mandell Center for Multiple Sclerosis at Mount Sinai Rehabilitation Hospital

Hartford, Connecticut, 06112, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical Diagnosis of MS
EDSS level between 3.5 - 6.0
Unilateral foot-drop
Able to ambulate 25 ft. with no more than a unilateral assistive device

Exclusion criteria

Lower extremity injuries that limit range of motion or function
Unable to demonstrate an understanding of the process of the study and/or fully understand instructions in order to safely participate in the study and use study equipment
Unable to fit safely and properly into the Ankle-Bot device

Treatment and study plan

Ankle-bot

Device

The Ankle-bot is a piece of robotic therapy equipment for the ankle. In this study, it will be used to guide and assist the subject into ankle flexion, extension, inversion and eversion.

Conventional focused ankle therapy

Other

Conventional focused ankle therapy will be performed by a physical therapist.

Primary outcomes

Gait Parameters

Time frame: Baseline, throughout study enrollment, and at 1 month and 3 month follow-up

Sponsors and collaborators

Lead sponsor

Mount Sinai Rehabilitation Hospital

Other

Registry information

Official study title

Targeted Lower Extremity Joint Training Effects on MS Gait Abnormalities

Important dates

Study start: 2009
Primary completion: 2012
Study completion: 2012
First posted: May 21, 2009
Registry last updated: Apr 9, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed