Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.

During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.

The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.

Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.

Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.

Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

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Key information

Conditions

Sleep Deprivation Dyssomnias Healthy Volunteers Mental Disorders Nervous System Diseases Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Skeletal Muscle Sleep Wake Disorders

Age range

25 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier de Poitiers

Poitiers, Vienne, 86021, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult male volunteers;
25 to 45 years old
regularly sleeping more than 6 hours per night;
no excessive consumers of coffee (<3 espressos / day);
absence of muscular or neurological pathology ;
with a BMI> 18 and <25 kg / m²;
Horne and Ostberg score> 31 and <69 ;

Exclusion criteria

female sex
history of neuromuscular disease ;
implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
history of epilepsy, or discomfort after sleep deprivation ;
poor sleepers (PSQI> 5);
exercising an activity in staggered hours;
regularly performing more than 2 nights without sleep per month;
taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
having crossed 4 time zones in the previous 4 weeks.
current participation in another clinical research study;

Treatment and study plan

Normal sleep night

Behavioral

Usual hours of sleep

Sleepless night

Behavioral

Total sleep deprivation the first night

Primary outcomes

Test duration

Time frame: 1 hour.

Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds.

Sponsors and collaborators

Lead sponsor

Poitiers University Hospital

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2020
First posted: Jan 19, 2018
Registry last updated: Apr 21, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed