Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers.

Sleep in intensive care unit is altered and few studies have suggested that sleep deprivation (SD) could impact respiratory muscle endurance. A lack of inspiratory endurance could lengthen weaning from invasive ventilation. The purpose of this study is to confirm whether SD alters inspiratory endurance and to identify brain mechanisms involved in SD-induced decreased endurance. A group of 20 male healthy subjects will perform an inspiratory load trial after a normal sleep night and after a sleepless night. Electrophysiological parameters (EEG, motor evoked potentials) of the inspiratory motor command and sensory perceptions will be assessed before, during and after each trial.

Inclusion criteria

• Male adult volunteers
• Aged 25 to 45 years
• Regularly sleeping more than 6 hours per night
• Not excessive coffee consumers (< 3 expressos / day)
• Non smokers
• Absence of respiratory, cardiac, muscular or neurological disease or diabetes
• With a neutral Horne & Ostberg score

Exclusion criteria

• Previous history of respiratory disease or otorhinolaryngological (asthma, respiratory allergies, swallowing disorders, oropharyngeal malformations)
• History of epilepsy or syncope during sleep deprivation
• Taking medications that interfere with sleep (antidepressants, benzodiazepines…)