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Completed

NCT Number: NCT06664281

Effects of SIT Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity

Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity.

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Key information

Conditions

Age range

18 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

School of Sports Medicine and Rehabilitation, Beijing Sport University

Beijing, China

About this study

This is a randomized clinical trial of single-blind with 3 arms (control group, SIT group and SIT with RIPC group), in which a pre-treatment-posttest design has been used.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Females aged between 18 and 30 years;
  • BMI within the normal range (18.5~24.9 kg/m²), BF% > 30%;
  • Participants with no clinically diagnosed contraindications for exercise, in good health, and not engaged in regular exercise, as determined by the health and physical activity questionnaire (based on the American College of Sports Medicine's guidelines for exercise testing and prescription).

Exclusion criteria

  • History of cardiovascular diseases, including coronary heart disease, stroke, or peripheral arterial disease diagnosed through vascular imaging techniques;
  • Currently participating in other intervention studies, including dietary, nutritional, or psychological education programs;
  • Those with regular professional training;
  • Musculoskeletal disorders that make long-term exercise interventions unsuitable.

Treatment and study plan

SIT

Behavioral

sprint interval training

SIT combined RIPC

Behavioral

sprint interval training combined with remote ischemic preconditioning

Primary outcomes

  1. Intima-Media Thickness (IMT)

    Time frame: 8 weeks

    Changes in Intima media thickness before and after intervention.

  2. Flow-Mediated Dilation (FMD)

    Time frame: 8 weeks

    Changes in Flow-mediated dilation before and after Intervention. Brachial artery flow-mediated dilation (FMD) was measured by the UNEXEF high-resolution ultrasound vascular endothelial function analyzer.

Secondary outcomes

  1. Body Composition Indicator

    Time frame: 8 weeks

    Changes in Body composition indicators before and after Intervention. Including body fat percentage (BF%).

  2. Human Morphometric i Indicators

    Time frame: 8 weeks

    Changes in Human morphometric indicators before and after Intervention. Including height, weight, waist circumference, hip circumference, and body mass index (BMI). BMI was calculated based on the measured height and weight using the formula: BMI = weight/height² (kg/m²).

  3. Blood Pressure (BP)

    Time frame: 8 weeks

    Changes in blood pressure before and after intervention. Including systolic and diastolic blood pressure.

  4. Nitric Oxide (NO)

    Time frame: 8 weeks

    Changes in concentration of nitric oxide before and after Intervention.

  5. Maximum Oxygen Uptake (VO2max)

    Time frame: 8 weeks

    Changes in maximum oxygen uptake before and after Intervention.

Sponsors and collaborators

Lead sponsor

Beijing Sport University

Other

Registry information

Official study title

Effects of Sprint Interval Training Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Oct 29, 2024
Registry last updated
Oct 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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