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OpenTrials
Completed

NCT Number: NCT07195773

Effects of rTMS on Balance Performance and Functional Mobility in Parkinson's Disease

This study aimed to investigate the effects of rTMS on balance performance and functional mobility in people with PD. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on balance performance and functional mobility.

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Key information

Conditions

Parkinson Disease Balance Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Excitability Mental Disorders Motor Cortex Motor Skills Disorders Movement Disorders Nervous System Diseases Neurodegenerative Diseases Neurodevelopmental Disorders Parkinsonian Disorders Synucleinopathies

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chung Shan Medical Unirversity

Taichung, Southern District, 40201, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with primary Parkinson's disease
  • Age: 40-85 years
  • Hoehn and Yahr scale (H&Y scale) : I-III
  • Appropriate prescribed medication, and regular intake for more than 2 weeks
  • Can walk more than 10m with or without the use of assistive devices

Exclusion criteria

  • Any other neurological presentation (Excluding PD)
  • Any neurological surgery that would affect participation in this experiment
  • Orthopedic pathology and Cardiovascular issues
  • MMSE≦24
  • Exercise used for treatment in the last three months
  • Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)

Treatment and study plan

rTMS

Device

Participants will receive different stimulation approaches in sequences: high-frequency rTMS, low-frequency rTMS, and sham rTMS. They will be randomly assigned to three groups with different stimulation sequences. After each single stimulation, balance performance, functional mobility, and motor symptoms will be measured. In this study, eighteen PD patients with Hoehn and Yahr stage 1 to 3 will be recruited.

Primary outcomes

  1. Dynamic balance

    Time frame: FRT will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

    Functional Reach Test

  2. Functional mobility

    Time frame: TUG will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

    Timed Up and Go test

  3. Motor function

    Time frame: UPDRS-III will be assessed before and immediately after each intervention. Each intervention is separated by a 2-week washout period. All assessments occur within an 4-week period.

    UPDRS-III

Sponsors and collaborators

Lead sponsor

Chung Shan Medical University

Other

Registry information

Official study title

Effects of Repetitive Transcranial Magnetic Stimulation on Balance Performance and Functional Mobility in People With Parkinson's Disease : A Double-Blind Randomized Crossover Pilot Study

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 29, 2025
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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