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Completed

NCT Number: NCT02160379

Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures

This is a cross-sectional study enrolling

* 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB) * 11 age- and weight-matched female subjects * 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal * electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures * plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are * to evaluate the effects of RYGB on brain perception of food related visual stimulation * to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

CHUV-clinical research center

Lausanne, Canton of Vaud, CH-1001, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • good apparent health
  • gender: female
  • age 18-50
  • non-smoker

Exclusion criteria

  • diabetes or antidiabetic medication
  • consumption of more than 50g alcohol per week
  • vegetarian or any special diet

Treatment and study plan

standard test meal

Other

Primary outcomes

  1. Changes of visually-evoked EEG potentials after ingestion of a meal

    Time frame: basal, 120 min postprandial and 240 postprandial

    Recording and analysis of visual evoked potentials (VEPs) while patients categorize photographs of foods and non-food kitchen utensils

Secondary outcomes

  1. changes in plasma triglyceride concentration after ingestion of a meal

    Time frame: basal, 90 min postprandial and 180 postprandial

    Measurement of triglyceride concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)

  2. Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal

    Time frame: basal, 90 min postprandial and 180 postprandial

    Measurement of GLP1 and GIP concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)

  3. Changes in plasma cholecystokinin concentrations after ingestion of a meal

    Time frame: basal, 90 min postprandial and 180 postprandial

    Measurement of cholecystokinin concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)

  4. Changes in plasma bile acids concentrations after ingestion of a meal

    Time frame: basal, 90 min postprandial and 180 postprandial

    Measurement of bile acids concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)

  5. changes in plasma glucoregulatory status after ingestion of a meal

    Time frame: basal, 90 min postprandial and 180 postprandial

    Measurement of glucose, insulin, glucagon and non-esterified fatty acid concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Registry information

Official study title

Dynamic Effect of Gastrointestinal Hormones on Cerebral Mechanisms Involved in Brain Perception of Food Pictures After Bariatric Surgery

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jun 10, 2014
Registry last updated
Jun 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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