Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty

Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.

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Key information

Conditions

Myotoxicity Chemically-Induced Disorders Drug-Related Side Effects and Adverse Reactions Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Radiation Injuries Wounds and Injuries

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsun University

Samsun, Turkey (Türkiye)

About this study

During 2 months period all elligible patients undergoing knee artoplasty surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma CPK levels will be tested 3 times of all patients.(preoperative, postoperative 6th hour, postoperative 24th hour) this data will be recorded for 2 months. After this period of time data will be analysed and patients will be grouped according to the analgesic modalities used.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA 1-3
knee artoplasty patients
under spinal anesthesia

Exclusion criteria

local anesthetic allergies
myopathies
coagulopathies
Obstructive sleep apne syndrome
hearth diseases
liver diseases
kidney diseases
thyroid-parathyriod dieseas
hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
pregnancy

Treatment and study plan

suprainguinal fascia iliaca block

Other

Suprainguinal fascia iliaca block will be performed after the end of surgery for postoperative analgesia.

Primary outcomes

CPK levels

Time frame: at postoperative 24th hour

Change from Baseline serum creatine phosphokinase at 24 hours

Secondary outcomes

Number of patients requesting rescue analgesics

Time frame: up to 24 hours

Intravenous administration of meperidine 25 mg as a rescue analgesic is planned for patients who complain of severe pain despite multimodal analgesia.

Sponsors and collaborators

Lead sponsor

Samsun University

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2023
First posted: Aug 18, 2022
Registry last updated: Feb 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed