CPK Levels After LC and Association With Analgesic Modalities

Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. The investigators aimed to examine plasma creatine phosphokinase (CPK) levels to see whether myotoxicity occurs or not after fascial plane blocks are applied to patients undergoing laparoscopic cholecystectomy.

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Key information

Conditions

Myotoxicity Chemically-Induced Disorders Drug-Related Side Effects and Adverse Reactions Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Radiation Injuries Wounds and Injuries

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsun University

Samsun, Turkey (Türkiye)

About this study

During 3 months period all elligible patients undergoing laparoscopic cholecystectomy surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma creatin phosphokinase (CPK) levels will be tested 3 times of all patients(preoperative, postoperative 6th hour, postoperative 24th hour). Data will be analysed and patients will be grouped according to the analgesic modalities used.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ASA 1-3
Laparoscopic cholecystectomy
under General Anesthesia

Exclusion criteria

Morbidly obesity or cachexia
local anesthetic allergies
myopathies
coagulopathies
Obstructive sleep apne syndrome
hearth diseases
liver diseases
kidney diseases
thyroid-parathyriod dieseas
hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
pregnancy

Treatment and study plan

İnterfascial plane block

Other

Interfascial plane blocks will be added to the routine analgesia plan as part of multimodal analgesia.

Standart analgesia plan

Other

This is the routine analgesia plan applied in our clinic.

Primary outcomes

CPK levels

Time frame: at postoperative 24th hour

Serum creatine phosphokinase levels at 24th hour

Sponsors and collaborators

Lead sponsor

Samsun University

Other

Registry information

Official study title

Does Postoperative Analgesic Modalities Effect Blood Creatin Phosphokinase Levels After Laparoscopic Cholecystectomy Surgery?

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Jul 18, 2024
Registry last updated: Jun 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed