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Completed

NCT Number: NCT05004220

Effects of Plasmapheresis on Aging Biomarkers

The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.

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Key information

Conditions

Aging Plasmapheresis

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Charles University, Medical Faculty in Hradec Kralove

Hradec Králové, Czechia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Generally healthy volunteer subjects age 40 - 60
  • 50:50 man and woman

Exclusion criteria

  • Subjects excluded from plasma donation protocols (serious illness, infection, etc)
  • Subjects undergoing stronger anti-aging interventions

Treatment and study plan

Plasmapheresis

Procedure

Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor.

Primary outcomes

  1. Significant change of biological age according to epigenetic clock after 8 plasmaphereses

    Time frame: Through study completion, an average of 8 months

    Significant change of the epigenetic age of the plasma donors after 8 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.

Secondary outcomes

  1. Significant change of biological age according to epigenetic clock after 8 plasmaphereses

    Time frame: Through study completion, an average of 8 months

    Significant change of the epigenetic age of the plasma donors after 4 cycles of plasmapheresis conducted or a slower increase of the biological age throughout the study than the increase of the chronological age.

  2. Significant change of the proteomic profile after 8 plasmaphereses

    Time frame: Through study completion, an average of 8 months

    Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.

  3. Significant change of the proteomic profile after 4 plasmaphereses

    Time frame: Through study completion, an average of 8 months

    Proteomic analysis showing signs of a rejuvenated proteostasis in the plasma donors after 8 cycles of plasmapheresis.

  4. Significant change of the biological age according to a blood biochemistry clock after 8 plasmaphereses

    Time frame: Through study completion, an average of 8 months

    Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.

  5. Significant change of the biological age according to a blood biochemistry clock after 4 plasmaphereses

    Time frame: Through study completion, an average of 8 months

    Blood biochemistry clock showing phenotype of a younger individual in the plasma donors after 8 cycles of plasmapheresis.

Sponsors and collaborators

Lead sponsor

Charles University, Czech Republic

Other

Collaborators

  • AGECURVE LIMITED
  • Clock Foundation
  • Longevitytech.fund a.s.
  • University Hospital Hradec Kralove

Registry information

Official study title

Studie Vlivu darování krevní Plazmy - Plasmapheresis. Study of the Plasma Donation Effect - Plasmapheresis

Important dates

Study start
2021
Primary completion
2021
Study completion
2023
First posted
Aug 13, 2021
Registry last updated
Sep 6, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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