Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.

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Key information

Conditions

Obstructive Sleep Apnea Apnea Behavior Dyssomnias Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Disorders, Intrinsic Sleep Wake Disorders Smoking

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Queen Mary Hospital

Hong Kong, 852

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

No acute illness
No hospitalization in past 4 weeks
Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

Exclusion criteria

Mentally incapacitated

Treatment and study plan

Primary outcomes

reactive hyperemia induced peripheral arterial tone (RH-RAT) index

Time frame: baseline

Secondary outcomes

circulatory metabolic and vascular inflammatory biomarkers

Time frame: baseline

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Official study title

Effects of Intermittent Hypoxia and/or Cigarette Smoking on Endothelial Injury in Vivo - Relevance to Obstructive Sleep Apnea

Important dates

Study start: 2008
Primary completion: 2011
First posted: Aug 12, 2009
Registry last updated: Dec 30, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed