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Completed

NCT Number: NCT05627804

Effects of Normobaric Hypoxia and Different Exercise Modes on Blood Glucose Regulation in Overweight Adults

Obesity is a major global health issue and a primary risk factor for metabolic-related disorders. While physical inactivity is one of the main contributors to obesity, it is a modifiable risk factor with exercise training as an established, non-pharmacological treatment to prevent the onset of metabolic-related disorders, including obesity. Exposure to low-oxygen availability (hypoxia) via normobaric hypoxia (simulated altitude via reduced inspired oxygen fraction), termed hypoxic conditioning, in combination with exercise has been increasingly shown in the last decade to enhance blood glucose regulation and decrease body mass index, providing a feasible strategy to treat obesity.

However, findings from studies investigating the potential for hypoxia to augment the exercise training response and subsequent metabolic health are equivocal. Notably, there is a lack of information regarding the optimal combination of exercise variables and hypoxic severity to enable an individualized and safe practice of exercising in a hypoxic environment.

In the present randomized, single-blind, cross-over study, the investigators will investigate the effects of single-bout of different exercise modes under moderate hypoxia (FiO2, 16.5%).

The investigators hypothesize that all exercises combined with hypoxia improve glucose homeostasis in overweight individuals.

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Key information

Conditions

Overweight Behavior Body Weight Healthy Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Pathological Conditions, Signs and Symptoms Physical Inactivity Sedentary Behavior Signs and Symptoms

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Sports Institute of Malaysia

Kuala Lumpur, 57000, Malaysia

About this study

In the present randomized, single-blind, cross-over study, participants will be exposed to moderate hypoxia (oxygen level 16.5%) during three different exercises (low-intensity cycling, sprint interval and functional exercises). Participants will be randomly assigned to each exercise condition (computer-generated randomization plan), separated by a washout period (5-7 days). To accomplish this, participants will exercise in an environmental chamber in which oxygen concentration of the ambient air and, as such, oxygen levels can be closely controlled and monitored.

Participants are required to attend the laboratory 8 times. These visits are including pre-exercise screening, baseline blood sampling, body composition screening and exercise in altitude conditions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI is between 25-29 kg/m²
  • Physical inactive (physical activity <150 min/week)
  • No known heart or metabolic diseases (such as Type 2 diabetes)
  • Not currently taking any prescribed medication
  • No reported musculoskeletal injuries recently
  • Not exposed to hypoxia >1000 m prior to the study

Exclusion criteria

  • Impaired glucose tolerance (2 hour glucose: >7.8 - 11.1 mmol/L)
  • Type 2 diabetes mellitus
  • Obstructive sleep apnea
  • Chronic obstructive pulmonary disease

Treatment and study plan

Low-moderate intensity exercise

Other

The participants will perform low-intensity cycling exercise at 90% lactate threshold under moderate hypoxia

Sprint Interval Training

Other

The participants will perform sprint interval cycling exercise at a load of 7.5% bodyweight under moderate hypoxia.

Functional Exercise

Other

The participants will perform bodyweight exercises under moderate hypoxia.

Control

Other

No exercise will be performed.

Primary outcomes

  1. Oral glucose tolerance test (glucose)

    Time frame: Change of fasting and postprandial plasma glucose concentrations compared to different exercise mode at immediately after exercise

    Change of plasma glucose concentration immediately post-exercise under different exercise modes

  2. Oral glucose tolerance test (insulin)

    Time frame: Change of fasting and postprandial plasma insulin concentrations compared to different exercise mode at immediately after exercise

    Change of plasma insulin concentration immediately post-exercise under different exercise modes

Sponsors and collaborators

Lead sponsor

Swinburne University of Technology

Other

Collaborators

  • National Sports Institute of Malaysia

Registry information

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Nov 28, 2022
Registry last updated
Nov 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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