Effects of Nicotinamide Riboside on Metabolism and Vascular Function

The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.

Inclusion criteria

• Age 18 to 35 (young) and 60 to 75 (older)
• Normo- or pre-hypertensive (blood pressure <140/90 mmHg)
• Non-smokers
• Able to give informed consent and participate in all laboratory visits

Exclusion criteria

• Currently taking any medications that could interfere with cardiovascular or metabolic outcomes will be excluded from the study (e.g., beta-blockers)
• Known metabolic (e.g. Type I or Type II diabetes, cardiovascular disease, etc.) or immunologic (e.g. HIV, cancer, autoimmune, etc.) diseases
• Food allergies to egg, milk, soy or wheat
• Women who are pregnant or planning to become pregnant during the course of the study,
• Pacemaker or other implanted device
• Unwilling to participate in the experimental protocol or blood draws will be excluded