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NCT Number: NCT03375866

Effects of Mixed Nut Consumption on Satiety and Weight Management

The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.

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Key information

Conditions

Satiety

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

School of Exercise and Nutritional Sciences, SDSU

San Diego, California, 92182-7251, United States

Location status: Recruiting

Location contact

Mee Young Hong

CONTACT

[email protected]

619-594-2392

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-55 years old
  • BMI 27-40

Exclusion criteria

  • Smoker
  • Pregnant woman
  • Required dietary supplement use
  • Required medication of metabolic disorders
  • Allergy to nuts or gluten

Treatment and study plan

Pretzels

Other

Subjects consume 240 kcal of pretzels daily for 16 weeks.

Mixed nuts

Other

Subjects consume 240 kcal of mixed nuts daily for 16 weeks.

Primary outcomes

  1. Change of Satiety

    Time frame: 0, 20, 40, 60, 90 and 120 minutes post snack consumption

    Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest

  2. Change of glucose level

    Time frame: Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption

    Glucose level will be examined using glucose analysis

  3. Change of insulin level

    Time frame: Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption

    Insulin level will be examined using an ELISA biochemical method

  4. Change of cholesterol levels

    Time frame: 8 weeks and 16 weeks post daily consumption

    Cholesterol levels will be examined using a biochemical method

  5. Change of Lp(a)

    Time frame: 8 weeks and 16 weeks post daily consumption

    Lp(a) levels will be examined using an ELISA biochemical method

Secondary outcomes

  1. Change of microbiome

    Time frame: 8 weeks and 16 weeks post daily consumption

    Diversity of microbiome will be analyzed in fecal samples

Study contacts

Contact information is provided by the study sponsor or research team.

Mee Young Hong

CONTACT

[email protected]

619-594-2392

Sponsors and collaborators

Lead sponsor

San Diego State University

Other

Registry information

Important dates

Study start
2016
Primary completion
2028
Study completion
2028
First posted
Dec 18, 2017
Registry last updated
Jan 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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