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Completed

NCT Number: NCT02100293

Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium

This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.

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Key information

Conditions

Observation of Neuromuscular Block Intubation Condition Surgical Condition

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National Univ. Bundang Hospita

Seongnam-si, Gyeonggi-do, 463-707, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-75 yr American Society of Anesthesiologists physical status 1 or 2, BMI of 20-24.9 kg/m2 scheduled for elective laryngeal microsurgery

Exclusion criteria

  • severe respiratory or cardiac disease hepatic or renal function impairment neuromuscular disease on medications affecting neuromuscular function with known allergy to the drugs

Treatment and study plan

magnesium sulfate 30 mg/kg

Drug

Patients in each group received the magnesium sulfate 30 mg/kg for 2 min in 0.9% normal saline (total volume 100 ml) intravenously for 5 min before induction of anesthesia

Saline

Drug

Patients in each group received 0.9% normal saline (total volume 100 ml) alone intravenously for 5 min before induction of anesthesia

Primary outcomes

  1. onset time of rocuronium

    Time frame: from injection of rocuronium to T1 suppression more than 95% up to 10 minutes

    from injection of rocuronium to T1 suppression more than 95% up to 10 minutes

Secondary outcomes

  1. maximal suppression time and duration of rocuronium

    Time frame: time from the injection of rocuronium to T1 maximal suppression time and reversal of T1 25% up to 1 hours

Other outcomes

  1. intubation condition

    Time frame: intubation condition during induction of anesthesia up to 10 minutes

    We scored intubation condition on the basis of 4 items, laryngoscopy, vocal cord position, moving of limbs, and coughing.

  2. surgical condition

    Time frame: intraoperative surgical condition

    to score a surgical condition according to 7 point likers scale

  3. postoperative sore throat

    Time frame: postoperative sore throat up to 4 hours

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Mar 31, 2014
Registry last updated
Apr 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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