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Completed

NCT Number: NCT01174485

Effects of Liposuction and Exercise Training on Metabolism, Lipid Profile and Adiposity in Women

Liposuction is the most popular aesthetic surgery in Brasil and worldwide. Evidence showing that adipose tissue is a metabolically active tissue led to the suggestion that liposuction could be a viable method for the improvement of metabolic profile through the immediate loss of adipose tissue. Studies about the effects of liposuction on metabolic profile are conflicting. A few studies report the improvement of insulin sensitivity, inflammatory markers and lipid profile, others observe no changes and a few report the worsening of metabolic profile. In addition, animal studies show a compensatory growth of intact adipose tissue in response to lipectomy. Physical exercise improves insulin sensitivity, lipid profile, inflammatory balance, adipose tissue distribution and increases or preserves free fat mass. Therefore, liposuction and physical exercise seem to act on similar tissues of the body. To the investigators knowledge, there are no studies about the associated effects of liposuction and exercise in humans. However, one can suggest that exercise training associated with liposuction could: [1] attenuate or block the possible fat recovery or compensatory growth; [2] block or reverse the possible harmful effects of liposuction; or [3] exert an additive or synergistic effect to the possible beneficial effects induced by liposuction on metabolic and hormonal profile and inflammatory balance.

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Key information

Conditions

Healthy Subjects Behavior Body Weight Motor Activity Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–36 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

Escola de Educação Física e Esporte da Universidade de São Paulo

São Paulo, 05508-900, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 20 to 35-year old healthy subjects with a BMI of 22 to 28 Kg/m2;
  • Non-smokers;
  • Present stable body weight for 6 months (without variations exceeding 4 kg);
  • Be in use contraceptive pill for at least 6 months;

Exclusion criteria

  • Health problems that impede surgery or exercise training;
  • Be in chronic use of antibiotics or antiinflammatory medication.

Treatment and study plan

Exercise

Procedure

combined resistance and aerobic training

Primary outcomes

  1. Body composition

    Time frame: 2 months post-intervention

    Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas.

  2. Body composition

    Time frame: 6 months post-intervention

    Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas.

Secondary outcomes

  1. Insulin Sensitivity

    Time frame: 2 months post-intervention

    Insulin sensitivity will be assessed by an oral glucose tolerance test

  2. Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels

    Time frame: 2 months post-intervention

  3. Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels

    Time frame: 2 months post-intervention

  4. Insulin Sensitivity

    Time frame: 6 months post-intervention

    Insulin sensitivity will be assessed by an oral glucose tolerance test

  5. Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels

    Time frame: 6 months post-intervention

  6. Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels

    Time frame: 6 months post-intervention

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Aug 3, 2010
Registry last updated
May 13, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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