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Completed

NCT Number: NCT05177172

Effect of Oat Compounds on Postprandial Glucose Response

In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance

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Key information

Conditions

Healthy Subjects Body Weight Choroid Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Eye Diseases Eye Diseases, Hereditary Genetic Diseases, Inborn Glucose Metabolism Disorders Gyrate Atrophy Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Uveal Diseases

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lund University, Food Technology, Engineering and Nutrition

Lund, 22100, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy
  • BMI 20-28 kg/m2
  • Diet which follows the Nordic Nutrition Recommendations (non-vegetarian)

Exclusion criteria

  • fasting glucose > 6.1 mmol/L
  • metabolic diseases
  • gastrointestinal disease
  • chronic and/or psychological disease
  • food allergy
  • Vegetarian or vegan diets, or other special diets

Treatment and study plan

High beta glucans

Other

higher dose betaglucans

Low beta glucans

Other

lower dose beta glucans

Low beta glucans + low polar lipids

Other

low dose betaglucans in a combination with low dose of polar lipids

Polar lipids

Other

low dose polar lipids

Control

Other

No beta glucans or polar lipids

Primary outcomes

  1. Glucose tolerance

    Time frame: 3 hours. Fasting (time =0 minutes), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes

    Postprandial glucose concentrations (mmol/L). The incremental area under the curve will be calculated and expressed as mmol*minutes/litre.

Secondary outcomes

  1. Subjective appetite variables

    Time frame: 3 hours. Fasting (time =0 minutes), 15 minutes, 30 minutes, 45 minutes, 60 minutes, 90 minutes, 120 minutes, 150 minutes, 180 minutes

    Postprandial sensation of hunger, satiety, and desire to eat will be determined with a 100 millimeter visual analogue scale (VAS). The left end of the VAS scale represent "not at all" (e.g. hungry) and right end of the scale represented "extremely". One scale for each parameter will be used. The total area under the curve will be calculated, and the results will be expressed as millimeter*minutes.

Sponsors and collaborators

Lead sponsor

Lund University

Other

Registry information

Official study title

Synergistic Effect of Oat Beta-glucans and Oat Polar Lipids on Postprandial Glucose Response

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jan 4, 2022
Registry last updated
Jan 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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