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Completed

NCT Number: NCT01314820

Effects of Joint Effusion on Quadriceps Muscle

The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

50 year–75 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Seoul, 137-701, South Korea

About this study

Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 50 years old or older with knee osteoarthritis
  • knee pain without joint effusion confirmed by ultrasonography

Exclusion criteria

  • the presence of knee joint effusion determined using US
  • a history of knee injury or surgery
  • a history of knee injection within 3 months
  • a history of inflammatory arthritis
  • taking anticoagulants
  • balance or gait disturbance
  • diabetes mellitus

Treatment and study plan

normal saline injection

Other

20 cc normal saline injection into knee joint

Other names: normal saline

Sham Injection

Other

no saline injection

Other names: no normal saline

Primary outcomes

  1. the peak torque of the knee extensors

    Time frame: within 5 minutes after intervention

    to evaluate the effect of effusion on the peak torque of the knee extensors

Secondary outcomes

  1. the root mean square values of the vastus medialis and vastus lateralis muscles

    Time frame: within 5 minutes after intervention

    to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles

Sponsors and collaborators

Lead sponsor

The Catholic University of Korea

Other

Registry information

Official study title

Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Mar 15, 2011
Registry last updated
Mar 15, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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