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Completed

NCT Number: NCT01025375

Effects of Inulin on Satiety and Food Intake

To assess the effect of inulin on appetite profile ratings, food intake and satiety hormones.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University

Maastricht, Limburg, 6229ER, Netherlands

About this study

Based upon a slower digestion and the fermentation in the intestinal tract, food containing soluble dietary fibres, such as inulin, is hypothesized to be more satiating, and to limit energy intake, in humans. Does supplementation of inulin (at 2 dosages) versus placebo over 13 consecutive days in normal to overweight men and women, lead to an increase in satiety, a reduction in food intake and stronger postprandial increases in GLP-1 and PYY?

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age between 18 and 60 years
  • BMI between 23 and 28 kg/m2
  • dietary unrestraint (TFEQ: F1<9)

Exclusion criteria

  • age under 18 and above 60 years
  • BMI under 23 and above 28 kg/m2
  • dietary restraint (TFEQ: F1>9)
  • use of medication
  • pregnant or breastfeeding

Treatment and study plan

Inulin

Dietary Supplement

10gram/day inulin for 13-day treatment

Other names: oligofructose

Placebo

Dietary Supplement

16gram/day maltodextrin (placebo) for 13-day treatment

Other names: maltodextrin

Primary outcomes

  1. food intake

    Time frame: on testday 0 and 13

Secondary outcomes

  1. appetite profile ratings

    Time frame: on test day 0, 8 and 13 (at 16 time points)

  2. satiety hormones (GLP-1 and PYY)

    Time frame: on test day 0 and 13 (at 9 time points

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Acronym: Inulin

Important dates

Study start
2009
Primary completion
2010
Study completion
2010
First posted
Dec 3, 2009
Registry last updated
Aug 30, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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