Skip to main content
OpenTrials
Completed

NCT Number: NCT01531491

Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol

Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Anesthesia, Intravenous Anesthesia Recovery Period Hypercapnia Hypocapnia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Dept. of anesthesiology and pain medicine, Dongguk University Ilsan Hospital

Goyang, Kyunggido, 140-773, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • American Society of Anesthesiologists physical status (ASA PS) I-II
  • Age 20 - 60 years male and female
  • Elective schedule with minor surgery under general anesthesia

Exclusion criteria

  • Body mass index (BMI) >= 30 (kg/m2)
  • Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
  • Patient with medication affecting on this study
  • Patient with general anesthesia history within one month

Treatment and study plan

Rebreathing tube

Procedure

750 ml rebreathing tube will be connected between the corrugated tube and the tracheal tube of a patient. Target partial pressure of the end-tidal carbon dioxide is 50 mmHg.

No rebreathing tube (Nothing)

Procedure

750 ml rebreathing tube will not be connected between the corrugated tube and the tracheal tube of a patient. Target partial pressure of the end-tidal carbon dioxide is 30 mmHg.

Primary outcomes

  1. Time to open eyes under investigator's command

    Time frame: From cessation of propofol infusion to patient's eye opening (seconds)

    After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes.

Secondary outcomes

  1. Time to breath spontaneously

    Time frame: From cessation of propofol infusion to patient's spontaneous breathing (sec)

    The time from cessation of propofol infusion to patient's spontaneous breaths will be recorded. The patients will be followed for an expected average of 10 minutes.

  2. Change of bispectral index (BIS)

    Time frame: From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded.

    After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes.

  3. Time to open mouth under investigator's command

    Time frame: From cessation of propofol infusion to patient's mouth opening (seconds)

    After the patient opens the eyes, every 10 seconds, the investigator command the patient, "Open your mouth.". When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 12 minutes.

  4. Time to extubation

    Time frame: From cessation of propofol infusion to extubation (sec)

    After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes.

Sponsors and collaborators

Lead sponsor

DongGuk University

Other

Registry information

Official study title

Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol: a Pilot Study

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Feb 13, 2012
Registry last updated
Feb 16, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.