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NCT Number: NCT02527083

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery. The primary aim of this study is to determine the effect of anesthesia type on long term pain after hernia surgery. In this study, patients undergoing inguinal hernia repair will be randomized to an anesthetic group, either Total Intravenous Anesthesia (TIVA) maintained with propofol or Balanced Inhaled Anesthesia (BIA) maintained with sevoflurane. This will allow us to look at any differences in short and long-term pain after hernia repair depending on type of anesthesia received.

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Key information

Conditions

Acute Pain Anesthesia, Intratracheal Anesthesia, Intravenous Chronic Pain Hernia Neurologic Manifestations Pain Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All male patients undergoing herniorrhaphy surgery that requires general anesthesia.

Exclusion criteria

  • Subjects unable to communicate directly with the investigators, due to being non-English speaking, loss of hearing, or incompetence.
  • A history of malignant hyperthermia, pseudocholinesterase deficiency, or other disease that prevents anesthetic randomization.
  • Pain-related disorders such as fibromyalgia or other chronic pain syndromes.
  • Emergency surgery.

Treatment and study plan

Propofol

Drug

Other names: Diprivan

Sevoflurane

Drug

Other names: Ultane

Remifentanil

Drug

Other names: Ultiva

ketamine

Drug

Other names: Ketalar

Primary outcomes

  1. Pain Score, Chronic

    Time frame: 1 month, 3 months, 6 months, 12 months

    Pain as measured by the Intensity Score of the Pain Quality Assessment Scale (PQAS) at each of the time points after surgery. The scale goes from 0 (no pain) to 10 (the most intense pain sensation imaginable). Higher scores mean worse pain.

Secondary outcomes

  1. Pain Score, Acute

    Time frame: 1 day

    Acute Pain on Day 1, as measured by the Pain Quality Assessment Scale (PQAS). The scale goes from 0 (no pain) to 10 (the most intense pain sensation imaginable). Higher scores means worse pain.

Sponsors and collaborators

Lead sponsor

VA Pittsburgh Healthcare System

Fed

Registry information

Important dates

Study start
2015
Primary completion
2019
Study completion
2019
First posted
Aug 18, 2015
Registry last updated
Dec 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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