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Completed

NCT Number: NCT05891938

Effects of Hydrogen Gas Inhalation on Adults of Various Ages

Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages.

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Key information

Conditions

Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wonju College of Medicine, Wŏnju, Ganwon-do, South Korea

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About this study

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants including those dropped out (5%) were screened and enrolled. The selected participants were treated as a single group without randomization. Evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. Furthermore, evaluation of dementia-related biomarkers such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion

  • Age ranges 40-70 years
  • Healthy participants
  • Patients who are willing or able to follow the doctor's instructions
  • Fully understand the purpose and procedure of this clinical trial

Exclusion criteria

  • Participants excluded those who have any disease
  • Pregnant and lactating women

Treatment and study plan

H2 gas inhalation

Other

H2 gas inhalation treatment for 4 weeks in on community dwelling adults of various ages

Primary outcomes

  1. Measurement of white blood cell and its differential counts such as neutrophils (%), basophils (%)

    Time frame: 4 weeks

    4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages

  2. Measurement of oxidative stress markers such as reactive oxygen species (µM), and nitric oxide (µM)

    Time frame: 4 weeks

    4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages

Secondary outcomes

  1. Measurement of dementia biomarkers such as brain-derived neurotrophic factor (BDNF ng/mL)

    Time frame: 4 weeks

    4 weeks treatment of H2 gas treatment

  2. Measurement of dementia biomarkers such as brain-derived neurotrophic factor amyloid beta (Aβ (pg/mL))

    Time frame: 4 weeks

    4 weeks treatment of H2 gas treatment

  3. Measurement of inflammatory markers such as interleukin 6 (pg/mL)

    Time frame: 4 weeks

    4 weeks treatment of H2 gas treatment

Sponsors and collaborators

Lead sponsor

Wonju Severance Christian Hospital

Other

Registry information

Official study title

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 7, 2023
Registry last updated
Jun 7, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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