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NCT Number: NCT07455162

Effects of Gesture Plus Verbal Treatment (GVT) in Cantonese Speakers With Aphasia

This research aims to explore the relative efficacy of Verbal-only and GVT on naming difficulty in Cantonese-speaking people with aphasia (PWA).

The primary research question in this study is: "For Cantonese-speaking people with aphasia, what are the relative effects of verbal treatment compared to gesture plus verbal treatment (GVT) on verbal and gesture naming at different levels?"

People with aphasia will be engaged in a repeated measures experimental design. Participants will be engaged in two phases of training. In the first phase, participants will be assigned to receive verbal-only treatment. To minimize and prevent the carry-over effects caused by the first intervention, a one-month washout period will be implemented before the start of the second phase. After a washout period, participants will switch to GVT in the second phase.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with aphasia
  • Demonstrate Word finding Difficulty (WFD)
  • Able to repeat single words
  • Normal (or corrected) vision and hearing
  • Aphasia resulting from a unilateral left hemisphere stroke
  • Premorbidly fluent in spoken Cantonese
  • Without significant cognitive impairments
  • Chronic aphasia resulting from a unilateral left hemisphere stroke

Exclusion criteria

  • A history of other neurological disorders
  • With the above moderate to severe or severe motor speech impairment
  • With moderate to severe apraxia of speech
  • With very mild or very severe aphasia

Treatment and study plan

Verbal treatment

Behavioral

This study will involve the following naming interventions: 1) Semantic Features Analysis, 2) Modified Ortho-phonological cueing therapy and Phonological Component Analysis, and 3) Repetition with Cueing Hierarchy.

Gesture plus verbal treatment

Behavioral

This study will involve the following interventions:

  • Combined Semantic and Gesture treatment, 2) Combined Phonological and Gesture treatment, and 3) Combined Repetition and Gesture treatment.

Primary outcomes

  1. Changes in the scores of the Naming Probes

    Time frame: From enrollment to the end of treatment at 4 weeks

    The treatment effects on naming will be assessed through verbal naming and gesture production using the black and white drawing naming task. Responses will be counted as correct if they can be identified by the rater as the target word in verbal naming and convey the depicted concept through gesture production, even if the articulation or hand and arm movements are slightly distorted.

Secondary outcomes

  1. Changes in the scores of the Cantonese Aphasia Battery

    Time frame: From enrollment to the end of treatment at 4 weeks

    The Cantonese Aphasia Battery was conducted to evaluate improvements in various linguistic measures (e.g., question comprehension, step commands, repetition, etc.). The minimum and maximum values are 0 and 100, respectively, with higher scores indicating a better outcome.

  2. Changes in the scores of the Comprehensive Aphasia Test

    Time frame: From enrollment to the end of treatment at 4 weeks

    The Comprehensive Aphasia Test will be conducted to evaluate improvements in various cognitive and linguistic measures (e.g., semantic memory, word fluency, auditory comprehension, etc.). There are different subtests in the assessment, with a minimum value of 0, and maximum values ranging from 70 to 130, with higher scores indicating a better outcome.

  3. Changes in the scores of the Cantonese Boston Naming Test

    Time frame: From enrollment to the end of treatment at 4 weeks

    The Cantonese Boston Naming Test will be conducted to evaluate the generalization effects on naming ability. The minimum and maximum values are 0 and 30, respectively, with higher scores indicating a better outcome.

  4. Changes in the number of main concepts and gestures in discourse production tasks

    Time frame: From enrollment to the end of treatment at 4 weeks

    Discourse samples were collected from participants through various monologues. The discourse elicitation tasks included Main concept analysis, procedural (Ham and Egg Sandwich), narrative (Telling of the story "Tortoise and Hare"), and personal narrative (Sharing of an important event). This will help in assessing their word retrieval abilities at both the sentence and discourse levels, and their verbal and non-verbal communication skills in realistic contexts. Regarding discourse assessment, all samples will be video recorded using a camera. After that, the samples will undergo discourse analysis based on Chinese Linguistics Communication Measures, where conversational speech will be transcribed, and the linguistic index will be calculated and compared. Finally, the number of various types of gestures will also be computed and compared.

  5. Changes in the scores of the Functional Communication questionnaire

    Time frame: From enrollment to the end of treatment at 4 weeks

    Improvements in functional communication will be evaluated using the Functional Assessment of Communication Skills questionnaire. There are different subtests in the assessment, with minimum values of 0, and maximum values ranging from 35 to 147, with higher scores indicating a better outcome.

Study contacts

Contact information is provided by the study sponsor or research team.

Annie Zhiyao Hu

CONTACT

[email protected]

852-6068-8312

Sponsors and collaborators

Lead sponsor

Hong Kong University

Other

Registry information

Official study title

Contrasting Effects of Verbal Treatment and Gesture Plus Verbal Treatment for Word Retrieval in Cantonese Speakers With Aphasia

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Mar 6, 2026
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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