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OpenTrials
Completed

NCT Number: NCT01121003

Effects of Fructose and Exercise on Hepatic Lipid Metabolism

8 healthy male volunteers will be studied each on 3 occasions, ie

* after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity * after 4 days on a weight maintenance diet containing 30% fructose + low physical activity * after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Completed

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Key information

Conditions

Metabolism

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud, CH-1011, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age between 18 and 30 years
  • males
  • BMI between 19 and 25
  • low to moderate physical activity (< 3 sessions/week)

Exclusion criteria

  • smoking
  • consumption of alcohol>50g/week
  • consumption of drugs or illicit substances
  • food allergies

Treatment and study plan

weight maintenance, low sugar diet

Behavioral

weight maintenance, high fructose diet

Behavioral

weight maintenance, high fructose diet+ exercise

Behavioral

Primary outcomes

  1. Hepatic de novo lipogenesis

    Time frame: after 4 days on controlled diet+exercise

    Measurement of 13C VLDL palmitate after ingestion of 13C fructose

Secondary outcomes

  1. Plasma VLDL-triglyceride kinetics

    Time frame: after 4 days on controlled diet+exercise

    Modelling of 2H5-glycerol incorporation in VLDL afetr administration of a bolus of 2H5 glycerol

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Collaborators

  • Centre Hospitalier Universitaire Vaudois

Registry information

Official study title

Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism

Acronym: FRUCTEXER

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
May 11, 2010
Registry last updated
Oct 19, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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