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Completed

NCT Number: NCT06223282

Effects of Exercise on Energy Intake-Prescription of Resistance Exercise

Healthy young males will complete five trials in a randomized crossover counter-balanced order, including three different inter-set rest of resistance exercise in equal training volume, one repeated until failure and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that different inter-set rest and training volume would affect subjective appetite and energy intake.

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Key information

Conditions

Eating Behavior Behavior Behavior, Animal Feeding Behavior Food Reward

Age range

20 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan Normal University

Taipei, 106, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 20-30
  • Healthy male

Exclusion criteria

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Failure to conduct resistance exercise

Treatment and study plan

short inter-set rest resistance exercise

Other

Subjects in short inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 60 sec of rest between sets.

medium inter-set rest

Other

Subjects in medium inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 120 sec of rest between sets.

long inter-set rest

Other

Subjects in long inter-set rest trial performed 3 sets per exercise, 7 repetitions with load of 70%-1RM with 180 sec of rest between sets.

medium inter-set rest with failure

Other

Subjects in long inter-set rest trial performed 3 sets per exercise, repeated to failure with load of 70%-1RM with 120 sec of rest between sets.

Primary outcomes

  1. Subjective appetite

    Time frame: 4-hour during each study intervention

    The appetite perceptions were obtained through a 0-100 mm visual analog scale. The variables assessed included perceptions of hunger (i.e., "How hungry do you feel?"), satisfaction (i.e., "How satisfied do you feel?"), fullness (i.e., "How full do you feel?"), prospective food consumption (i.e., "How much do you think you can eat?"), and nausea (i.e., "How nauseous do you feel?"), with 0 indicating "not at all" and 100 signifying "extremely.".

  2. Change in acyl-Ghrelin

    Time frame: 4-hour during each study intervention

    acyl-Ghrelin in pg/mL

  3. Change in total-Ghrelin

    Time frame: 4-hour during each study intervention

    total-Ghrelin in pg/mL

  4. Change in PYY

    Time frame: 4-hour during each study intervention

    PYY in pg/mL

  5. Change in active-GLP-1

    Time frame: 4-hour during each study intervention

    active-GLP-1 in pg/mL

  6. Change in total-GLP-1

    Time frame: 4-hour during each study intervention

    total-GLP-1 in pg/mL

  7. Change in lactate

    Time frame: 4-hour during each study intervention

    insulin in mmol/L

Secondary outcomes

  1. Explicit liking

    Time frame: 4 hours during each study intervention

    A visual analog scale ranging from 0 to 100 mm was utilized to evaluate the question, "How pleasant would it be to taste some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."

  2. Explicit wanting

    Time frame: 4 hours during each study intervention

    A visual analog scale ranging from 0 to 100 mm was utilized to evaluate the question, "How much do you want some of this food now?" with 0 indicating "not at all" and 100 signifying "extremely."

  3. Implicit wanting

    Time frame: 4 hours during each study intervention

    Participants were given a set of food image pairs and were asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The implicit wanting calculation involved further consideration of response time data based on preference choices using a standardized equation.

  4. Relative preference

    Time frame: 4 hours during each study intervention

    Participants were given a set of food image pairs and were asked to select their preference by answering the question, "Which food do you desire the most at the moment?". The relative preference was the sum of the times each type of food was chosen, with a maximum value of 48 and a minimum value of 0.

  5. Fat appeal bias

    Time frame: 4 hours during each study intervention

    Fat preference (high or low) was calculated by subtracting the mean low-fat scores from the mean high-fat scores. Positive values suggest a preference for high-fat foods, while negative scores indicate a preference for low-fat or savory foods, and a score of 0 signifies an equal preference between fat content.

  6. Taste appeal bias

    Time frame: 4 hours during each study intervention

    Taste preference (savoury or sweet) was calculated by subtracting the mean savory scores from the mean sweet scores. Positive values suggest a preference for sweet foods, while negative scores indicate a preference for savory foods, and a score of 0 signifies an equal preference between taste categories.

  7. Change in glucose

    Time frame: 4 hours during each study intervention

    glucose in mg/dL

  8. Change in TG

    Time frame: 4 hours during each study intervention

    TG in mg/dL

  9. Change in insulin

    Time frame: 4 hours during each study intervention

    insulin in mU/L

  10. Energy intake

    Time frame: 3 days during each study intervention

    Participants are required to record their diet for the day before, the current day, and the day following the experiment.

Sponsors and collaborators

Lead sponsor

National Taiwan Normal University

Other

Registry information

Official study title

Effects of Acute Resistance Exercise With Varying Training Volume and Rest Intervals Under Equal Load on Appetite Control, Food Reward, and Energy Intake: a Five-arm Crossover Randomized Controlled Trial

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jan 25, 2024
Registry last updated
Jan 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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