Skip to main content
OpenTrials
Completed

NCT Number: NCT02589327

Effects of Exercise on Cardiac Fat in Women With Obesity: a Pilot Study

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–35 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Kinesiology and Sport Management

Lubbock, Texas, 79423, United States

About this study

Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. More effective treatments are needed to induce changes in cardiac fat content, body composition, and cardiac fat metabolic activity that result in a reduction in cardiovascular risk in overweight and obese population. Despite this need, little is known about which mode, frequency, and duration of exercise will allow for greater reductions in cardiac fat, improvements in body composition, restoration of a healthy cardiac fat metabolic activity, and improvement on cardiovascular risk markers. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI 30-39.99
  • White/Caucasian

Exclusion criteria

  • Known health problems such as cardiovascular, pulmonary or metabolic disease will be excluded.
  • Pregnant females.
  • Any adults found taking medications that affect endocrine or cardiovascular function will also be excluded from the study.
  • Participants that exercise more than three times per week or strength train more than twice per week.
  • Individuals that have poor venous access or have expressed a fear of needles or having blood taken will also be excluded.
  • Cigarette smoking (current or those who quit within the previous 6 months
  • Hypertension
  • Diabetics
  • MRI exclusion criteria must be observed: must complete a safety checklist that is designed to identify metal in your body that could pose a hazard during scanning. Some forms of metal are acceptable (e.g., dental fillings after 1970). Tattoos are generally not exclusionary, unless they have been inked with metallic dyes. All metal must be removed from your body. All female subjects, prior to scanning, are required to complete a pregnancy test. Must NOT be claustrophobic or have a history of claustrophobia

Treatment and study plan

Exercise intervention

Other

The intervention will consist of 3 weeks of whole body circuit training (resistance training) where participants in the intervention group will perform 7 different exercises. The circuit will consist of 10 repetitions per exercise of 7 exercises: leg press, bent-over row, bench press, squats, dumbbell jump squats with raises, dead-lifts and weighted abdominal crunches, with approximately 30 sec of rest in between each exercise (based on the estimated time needed to move from one position to the next). Each participant will move through the circuit 3 times, with 2 to 3 minutes of rest between each round. Intensity will be 6-7 of RPE at the first set, and 9-10 at the third set.

Primary outcomes

  1. Changes in Cardiac fat volumes

    Time frame: 2 assessment points: at baseline and week 4

    Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging

Secondary outcomes

  1. Changes in Vascular function

    Time frame: 2 assessment points: at baseline and week 4

    Vascular function will be assessed by means of Arterial Tonometry

  2. Changes in Cardiorespiratory Function

    Time frame: 2 assessment points: at baseline and week 4

    Cardiorespiratory Function will be assessed on a treadmill test with a 12-lead EKG. Protocol: Modified Bruce (A baseline stage will be added)

  3. Changes in Muscular Strength

    Time frame: 2 assessment points: at baseline and week 4

    Muscular Strength in upper and lower extremities will be assessed by 1 repetition maximum (1RM) test on Bench Press and Leg Press

  4. Changes in Body Composition

    Time frame: 2 assessment points: at baseline and week 4

    Body Composition will be assessed using Dual-energy x-ray absorptiometry

  5. Changes in Diet

    Time frame: 5 assessment points: baseline, week 1, 2, 3, and 4

    Diet will be assessed using the ASA24h recall (http://epi.grants.cancer.gov/asa24/)

  6. Changes in Spontaneous Physical Activity

    Time frame: Baseline and week 4

    Spontaneous Physical Activity will be assessed using accelerometers Actical.

  7. Changes in Oxidative stress markers

    Time frame: 5 assessment points: pre-post during session 1, pre-post during session 9, and pre week 4.

    Blood will be collected and processed in order to assess oxidative stress markers

Sponsors and collaborators

Lead sponsor

Texas Tech University

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Oct 28, 2015
Registry last updated
May 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.