Skip to main content
OpenTrials
Completed

NCT Number: NCT07435857

Effects of Exercise During Pregnancy on the Long-term Metabolic Health of Mothers and Their Offspring

The aim of this study was to assess the long-term metabolic effects of gestational exercise on overweight and obese women and their offspring 8-10 years post-intervention.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Metabolic Health Behavior Body Weight Motor Activity Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking University First Hospital

Beijing, 100034, China

About this study

We conducted a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent comprehensive metabolic evaluations, including anthropometric measurements (weight, skinfold thickness, and body composition), blood pressure assessment, oral glucose tolerance tests (OGTTs), insulin release tests (IRTs), and lipid profiling.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 132 mothers in the exercise group and 133 mothers in the control group in the previous RCT trial who had OGTT results and their offsprings were eligible for follow-up

Exclusion criteria

  • The criteria for exclusion from the follow-up study included loss to follow-up, refusal to participate, or major illness (acute lymphoblastic leukemia) of the mother or the child.

Treatment and study plan

Exercise

Behavioral

The present study is a prospective follow-up of a randomized controlled trial (RCT) that was conducted in the Department of Obstetrics and Gynecology, Peking University First Hospital, from December 2014 to April 2017. In this RCT, 300 obese/overweight pregnant women (prepregnancy BMI ≥24 kg/m²) at <12+6 weeks of gestation were randomized to exercise (n=150) and control groups (n=150), and the efficacy of regular exercise in early pregnancy to prevent GDM among overweight/obese pregnant Chinese women was investigated. The patients allocated to the exercise group were assigned to a cycling program (3 times per week, at least 30 min/session, rating of perceived exertion 12-14); the program was initiated within 3 days of randomization and continued until 37 weeks of gestation. The patients in the control group maintained their usual daily activities. The original RCT has been reported previously （Wang, C.Am. J. Obstet. Gynecol. 2017, 216 (4), 340-351.)

Primary outcomes

  1. OGTT

    Time frame: 8-10 years

    75-g oral glucose tolerance test （0h，2h，mmol/L）

Secondary outcomes

  1. BMI

    Time frame: 8-10 years

    weight in kilograms, height in meters, and weight and height will be combined to report BMI in kg/m2

  2. anthropometric measures

    Time frame: 8-10 years

    anthropometric measurements include waist circumference and skinfold thickness (centimeters) using skinfold caliper. Additionally，And use a body composition analyzer to measure body fat content and distribution （ The fat mass [kg]； fat percentage [%]； visceral fat area [cm2]； and lean mass [kg] were determined using bioimpedance analysis）.

  3. insulin resistance

    Time frame: 8-10 years

    plasma insulin levels were measured using electrochemiluminescence, and insulin resistance was calculated via the HOMA equation (fasting plasma insulin concentration (μIU/mL) × fasting glucose concentration (mmol/L)/22.5).

  4. lipid profile

    Time frame: 8-10 years

    fasting lipid profiles, including total cholesterol (TCHO), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured via the cholesterol oxidase method (mmol/L)

Sponsors and collaborators

Lead sponsor

Peking University First Hospital

Other

Registry information

Official study title

Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers and Their Offspring: An 8- to 10-year Follow-Up Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Feb 27, 2026
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.