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NCT Number: NCT07536542

Effects of Dual-Task Training on Upper Extremity Function in Parkinson's Disease

The goal of this clinical trial is to investigate the effects of dual-task training on upper extremity function and muscle thickness in individuals with Parkinson's disease. The main questions it aims to answer are:

Does dual-task training improve upper extremity function in individuals with Parkinson's disease? Does dual-task training lead to changes in upper extremity muscle thickness measured by ultrasonography?

Researchers will compare a dual-task training group with a control group receiving routine care to determine whether 8 weeks of dual-task training results in greater improvements in upper extremity outco

Participants will:

complete baseline and post-intervention assessments of upper extremity function, muscle thickness, grip strength, and pinch strength be assigned to either a control group or a dual-task training group receive dual-task training 3 days per week for 8 weeks if assigned to the intervention group

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Key information

Conditions

Parkinson Disease (PD) Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

40 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hacettepe University

Ankara, Turkey (Türkiye)

Location status: Recruiting

Location contact

Ayla Fil, Assoc.Prof. PhD

CONTACT

[email protected]

+905074708330

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosis of idiopathic Parkinson's disease confirmed by a neurologist
  • Modified Hoehn and Yahr stage 2 to 3
  • No medication or dosage change within the last 6 months
  • Cognitive capacity sufficient to understand and follow instructions, defined as Montreal Cognitive Assessment score ≥21
  • Voluntary participation with written informed consent

Exclusion criteria

  • Atypical or secondary parkinsonism
  • Advanced orthopedic condition affecting the upper extremity
  • Surgery, trauma, or immobilization involving the upper extremity within the last 6 months
  • Wound or dermatological condition preventing upper extremity ultrasonographic evaluation
  • Severe visual or hearing loss
  • Severe depression, psychosis, or communication difficulty
  • Any additional health problem preventing regular participation in the study

Treatment and study plan

Dual-Task Training

Behavioral

Dual-task training will be applied 3 times per week for 8 weeks, with each session lasting 60 minutes. The program combines motor tasks (such as peg placement, object manipulation, bilateral coordination, and mobility tasks) with simultaneous cognitive tasks (such as backward counting, category-based word generation, and memory tasks).

Primary outcomes

  1. Upper Extremity Function

    Time frame: Baseline and 8 weeks

    Upper extremity function will be assessed using the Purdue Pegboard Test. Performance will be recorded as the number of pins placed within the specified time for dominant hand, nondominant hand, and both hands; higher scores indicate better fine motor performance and manual dexterity.

  2. Upper Extremity Muscle Thickness

    Time frame: Baseline and 8 weeks

    Muscle thickness of the deltoid, biceps brachii, triceps brachii, and forearm flexor muscles will be measured using ultrasonography. The mean of three repeated measurements for each site will be recorded in millimeters.

  3. Hand Grip Strength

    Time frame: Baseline and 8 weeks

    Hand grip strength will be measured using a Jamar hydraulic hand dynamometer according to the ASHT protocol. The mean of three trials will be recorded.

  4. Pinch Strength

    Time frame: Baseline and 8 weeks

    Lateral pinch, three-jaw chuck pinch, and two-point pinch strength will be assessed using a pinch meter. The mean of three trials will be recorded in kilograms or Newtons.

Study contacts

Contact information is provided by the study sponsor or research team.

Büşra Seçkinoğulları Korkusuz, PhD

CONTACT

[email protected]

+905442436914

Sponsors and collaborators

Lead sponsor

Ankara University

Other

Collaborators

  • Hacettepe University

Registry information

Official study title

Effects of Dual-Task Training on Upper Extremity Function and Muscle Thickness in Parkinson's Disease

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 17, 2026
Registry last updated
Jun 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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