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Completed

NCT Number: NCT01495754

Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers

The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.

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Key information

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University

Athens, 17671, Greece

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • apparently healthy
  • habitual coffee drinkers (>= 1cup of coffee/day)

Exclusion criteria

  • smokers
  • restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)
  • those who reported slimming or any other dietary regime
  • athletes
  • participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl
  • subjects on medication for hypertension or on medication known to alter glucose metabolism
  • subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or
  • endocrine disease,
  • gastrointestinal disorders,
  • a history of medical or surgical events that may have affected the study outcomes

Treatment and study plan

Coffee

Other

Comparison of different amounts of coffee

Primary outcomes

  1. energy intake ad libitum

    Time frame: 180 min after breakfast/drink consumption

  2. total energy intake

    Time frame: One day

  3. appetite feelings

    Time frame: fasting (-15 min)

  4. appetite feelings

    Time frame: immediately after breakfast/drink consumption (0 min)

  5. appetite feelings

    Time frame: 15 min after breakfast/drink consumption

  6. appetite feelings

    Time frame: 30 min after breakfast/drink consumption

  7. appetite feelings

    Time frame: 60 min after breakfast/drink consumption

  8. appetite feelings

    Time frame: 90 min after breakfast/drink consumption

  9. appetite feelings

    Time frame: 120 min after breakfast/drink consumption

  10. appetite feelings

    Time frame: 150 min after breakfast/drink consumption

  11. appetite feelings

    Time frame: 180 min after breakfast/drink consumption

  12. appetite hormones

    Time frame: fasting (-15 min)

  13. appetite hormones

    Time frame: immediately after breakfast/drink consumption (0 min)

  14. appetite hormones

    Time frame: 15 min after breakfast/drink consumption

  15. appetite hormones

    Time frame: 30 min after breakfast/drink consumption

  16. appetite hormones

    Time frame: 60 min after breakfast/drink consumption

  17. appetite hormones

    Time frame: 90 min after breakfast/drink consumption

  18. appetite hormones

    Time frame: 120 min after breakfast/drink consumption

  19. appetite hormones

    Time frame: 150 min after breakfast/drink consumption

  20. appetite hormones

    Time frame: 180 min after breakfast/drink consumption

  21. markers of inflammation

    Time frame: fasting (-15 min)

  22. markers of inflammation

    Time frame: immediately after breakfast/drink consumption (0 min)

  23. markers of inflammation

    Time frame: 15 min after breakfast/drink consumption

  24. markers of inflammation

    Time frame: 30 min after breakfast/drink consumption

  25. markers of inflammation

    Time frame: 60 min after breakfast/drink consumption

  26. markers of inflammation

    Time frame: 90 min after breakfast/drink consumption

  27. markers of inflammation

    Time frame: 120 min after breakfast/drink consumption

  28. markers of inflammation

    Time frame: 150 min after breakfast/drink consumption

  29. markers of inflammation

    Time frame: 180 min after breakfast/drink consumption

  30. markers of glucose metabolism

    Time frame: fasting (-15 min)

  31. markers of glucose metabolism

    Time frame: immediately after breakfast/drink consumption (0 min)

  32. markers of glucose metabolism

    Time frame: 15 min after breakfast/drink consumption

  33. markers of glucose metabolism

    Time frame: 30 min after breakfast/drink consumption

  34. markers of glucose metabolism

    Time frame: 60 min after breakfast/drink consumption

  35. markers of glucose metabolism

    Time frame: 90 min after breakfast/drink consumption

  36. markers of glucose metabolism

    Time frame: 120 min after breakfast/drink consumption

  37. markers of glucose metabolism

    Time frame: 150 min after breakfast/drink consumption

  38. markers of glucose metabolism

    Time frame: 180 min after breakfast/drink consumption

Secondary outcomes

  1. % carbohydrates ad libitum

    Time frame: 180 min after breakfast/drink consumption

  2. % carbohydrates total day

    Time frame: One day

  3. % protein ad libitum

    Time frame: 180 min after breakfast/drink consumption

  4. % protein total day

    Time frame: One day

  5. % fat

    Time frame: 180 min after breakfast/drink consumption

  6. % fat total day

    Time frame: One day

Sponsors and collaborators

Lead sponsor

Harokopio University

Other

Registry information

Official study title

The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Dec 20, 2011
Registry last updated
Dec 20, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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