Effect of Reduction of Inflammatory Status on Glucose Metabolism in Overweight Men

Overweight increases the risk to develop chronic diseases including type-2 diabetes and cardiovascular disease. The low-grade inflammatory status often seen in overweight subjects is thought to play an important role in disease development.

The purpose of this study is to determine the role of inflammation on glucose metabolism and insulin resistance. In this study the effect of the anti-inflammatory treatment diclofenac on markers of inflammation and on parameters of glucose metabolism will be studied.

Completed

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Key information

Conditions

Overweight Body Weight Inflammation Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

TNO Quality of Life

Zeist, 3700 AJ, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Body Mass Index (BMI): 25.1 - 32.0 kg/m2
Normal Dutch eating habits

Exclusion criteria

diabetes, cardiovascular disease or hypertension
Not suitable to receive diclofenac treatment
Smoking
Extreme physical activity (more than 6 hours/week)
Reported slimming or medically prescribed diet

Treatment and study plan

Diclofenac

Drug

Sponsors and collaborators

Lead sponsor

TNO

Other

Registry information

Official study title

Relation Between Reduction of the Inflammatory Status and Glucose Metabolism in Healthy Overweight Men

Important dates

Study start: 2005
Study completion: 2005
First posted: Sep 22, 2005
Registry last updated: Oct 11, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed